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患者特异性多模态腹主动脉瘤成像模型。

A patient-specific multi-modality abdominal aortic aneurysm imaging phantom.

机构信息

Wellcome Trust-EPSRC Centre for Interventional and Surgical Sciences, London, W1W 7TS, UK.

Department of Medical Physics and Bioengineering, University College London, London, WC1E 6BT, UK.

出版信息

Int J Comput Assist Radiol Surg. 2022 Sep;17(9):1611-1617. doi: 10.1007/s11548-022-02612-4. Epub 2022 Apr 10.

Abstract

PURPOSE

Multimodality imaging of the vascular system is a rapidly growing area of innovation and research, which is increasing with awareness of the dangers of ionizing radiation. Phantom models that are applicable across multiple imaging modalities facilitate testing and comparisons in pre-clinical studies of new devices. Additionally, phantom models are of benefit to surgical trainees for gaining experience with new techniques. We propose a temperature-stable, high-fidelity method for creating complex abdominal aortic aneurysm phantoms that are compatible with both radiation-based, and ultrasound-based imaging modalities, using low cost materials.

METHODS

Volumetric CT data of an abdominal aortic aneurysm were acquired. Regions of interest were segmented to form a model compatible with 3D printing. The novel phantom fabrication method comprised a hybrid approach of using 3D printing of water-soluble materials to create wall-less, patient-derived vascular structures embedded within tailored tissue-mimicking materials to create realistic surrounding tissues. A non-soluble 3-D printed spine was included to provide a radiological landmark.

RESULTS

The phantom was found to provide realistic appearances with intravascular ultrasound, computed tomography and transcutaneous ultrasound. Furthermore, the utility of this phantom as a training model was demonstrated during a simulated endovascular aneurysm repair procedure with image fusion.

CONCLUSION

With the hybrid fabrication method demonstrated here, complex multimodality imaging patient-derived vascular phantoms can be successfully fabricated. These have potential roles in the benchtop development of emerging imaging technologies, refinement of novel minimally invasive surgical techniques and as clinical training tools.

摘要

目的

血管系统的多模态成像领域是一个快速发展的创新和研究领域,随着人们对电离辐射危险的认识不断提高,该领域的研究也在不断增加。适用于多种成像模式的体模模型有助于在新设备的临床前研究中进行测试和比较。此外,体模模型对于外科受训者来说也有好处,可以帮助他们获得新技术的经验。我们提出了一种温度稳定、高保真的方法,使用低成本材料创建与基于辐射和基于超声的成像模式兼容的复杂腹主动脉瘤体模。

方法

采集腹主动脉瘤的容积 CT 数据。对感兴趣区域进行分割,形成与 3D 打印兼容的模型。新的体模制作方法采用 3D 打印水溶性材料的混合方法,创建无壁、基于患者的血管结构,嵌入定制的组织模拟材料中,以创建逼真的周围组织。还包括一个不可溶性的 3D 打印脊柱,作为放射学标志物。

结果

该体模在血管内超声、计算机断层扫描和经皮超声检查中均呈现出逼真的外观。此外,在模拟血管内动脉瘤修复手术中进行图像融合时,该体模作为训练模型的效用得到了证明。

结论

通过这里展示的混合制造方法,可以成功制造出复杂的多模态成像患者来源的血管体模。这些体模在新兴成像技术的台架开发、新型微创技术的改进以及临床培训工具方面具有潜在的应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c2/9463301/05c7a5f49b06/11548_2022_2612_Fig1_HTML.jpg

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