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“蓬松”主动脉:灾难的理想“温床”。最新综述

Shaggy aorta: ideal substrate for disaster. Updated review.

作者信息

Velarde-Acosta Kevin, Moscoso Ramirez Josh Yefry, Rojas Paol, Susanibar Lucy, Reusche Lady Diana Quintana, Cachicatari Angela, Baltodano-Arellano Roberto

机构信息

Clinical Cardiology Department; Hospital Guillermo Almenara Irigoyen - EsSalud, Lima, Perú Clinical Cardiology Department Hospital Guillermo Almenara Irigoyen - EsSalud Lima Perú.

Interventional Cardiology Department; Hospital Guillermo Almenara Irigoyen - EsSalud, Lima, Perú Interventional Cardiology Department Hospital Guillermo Almenara Irigoyen - EsSalud Lima Perú.

出版信息

Arch Peru Cardiol Cir Cardiovasc. 2024 Sep 29;5(3):143-152. doi: 10.47487/apcyccv.v5i3.410. eCollection 2024 Jul-Sep.

DOI:10.47487/apcyccv.v5i3.410
PMID:39411013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11473078/
Abstract

Shaggy aorta (SA) is characterized by a critical and extensive atheromatous disease of the thoracic and abdominal aorta. This degenerative and dangerous pathology is the result of the confluence of multiple modifiable and non-modifiable risk factors. The clinical importance of this pathology relies on the various syndromes that can develop from its etiopathogenesis, which generates great morbidity and mortality in the affected patients. In this document, we present an updated and detailed review of this entity, developing aspects of its pathophysiology, diagnosis, including the importance of multimodal imaging, and its therapeutic approach. Finally, we present the clinical settings of patients with SA in different aortic scenarios (aortic dissection, ulcerated plaques, and thrombosed aneurysms) that denote the nature of this disease and its high mortality.

摘要

毛糙主动脉(SA)的特征是胸主动脉和腹主动脉存在严重且广泛的动脉粥样硬化疾病。这种退行性且危险的病理状况是多种可改变和不可改变的危险因素共同作用的结果。该病理状况的临床重要性取决于其病因发病机制可能引发的各种综合征,这在受影响的患者中会导致很高的发病率和死亡率。在本文档中,我们对这一实体进行了更新且详细的综述,阐述了其病理生理学、诊断方面(包括多模态成像的重要性)以及治疗方法。最后,我们介绍了SA患者在不同主动脉情况(主动脉夹层、溃疡斑块和血栓形成的动脉瘤)下的临床情况,这些情况表明了该疾病的性质及其高死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/308ee0698545/apcyccv-5-03-143-gf6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/1f0babe3c9e0/apcyccv-5-03-143-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/d93442b66e0c/apcyccv-5-03-143-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/6a2bcd36dcb6/apcyccv-5-03-143-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/1e2915de829e/apcyccv-5-03-143-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/0bb5b5e8e2f8/apcyccv-5-03-143-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/308ee0698545/apcyccv-5-03-143-gf6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/1f0babe3c9e0/apcyccv-5-03-143-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/d93442b66e0c/apcyccv-5-03-143-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/6a2bcd36dcb6/apcyccv-5-03-143-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/1e2915de829e/apcyccv-5-03-143-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/0bb5b5e8e2f8/apcyccv-5-03-143-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8471/11473078/308ee0698545/apcyccv-5-03-143-gf6.jpg

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本文引用的文献

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Acute Aortic Syndromes from Diagnosis to Treatment-A Comprehensive Review.从诊断到治疗的急性主动脉综合征——全面综述
J Clin Med. 2024 Feb 21;13(5):1231. doi: 10.3390/jcm13051231.
2
Platelet biology and function: plaque erosion vs. rupture.血小板生物学与功能:斑块侵蚀与破裂
Eur Heart J. 2024 Jan 1;45(1):18-31. doi: 10.1093/eurheartj/ehad720.
3
Novel Insights into the Molecular Mechanisms of Atherosclerosis.动脉粥样硬化分子机制的新见解。
Int J Mol Sci. 2023 Aug 30;24(17):13434. doi: 10.3390/ijms241713434.
4
Molecular and cellular mechanisms of inflammation in atherosclerosis.动脉粥样硬化中炎症的分子和细胞机制。
Front Cardiovasc Med. 2023 Aug 3;10:1200341. doi: 10.3389/fcvm.2023.1200341. eCollection 2023.
5
Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes.动脉粥样硬化与炎症:通论病理过程学说的启示。
Int J Mol Sci. 2023 Apr 26;24(9):7910. doi: 10.3390/ijms24097910.
6
Multimodality imaging in thoracic aortic diseases: a clinical consensus statement from the European Association of Cardiovascular Imaging and the European Society of Cardiology working group on aorta and peripheral vascular diseases.胸主动脉疾病的多模态影像学:欧洲心血管影像协会和欧洲心脏病学会主动脉及外周血管疾病工作组的临床共识声明。
Eur Heart J Cardiovasc Imaging. 2023 Apr 24;24(5):e65-e85. doi: 10.1093/ehjci/jead024.
7
The Role of Multimodality Imaging Approach in Acute Aortic Syndromes: Diagnosis, Complications, and Clinical Management.多模态成像方法在急性主动脉综合征中的作用:诊断、并发症及临床管理
Diagnostics (Basel). 2023 Feb 9;13(4):650. doi: 10.3390/diagnostics13040650.
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2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.2022 ACC/AHA 血管疾病诊断与管理指南:美国心脏协会/美国心脏病学会联合临床实践指南委员会的报告。
Circulation. 2022 Dec 13;146(24):e334-e482. doi: 10.1161/CIR.0000000000001106. Epub 2022 Nov 2.
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