Russell A D
Infection. 1986 Sep-Oct;14(5):212-5. doi: 10.1007/BF01644264.
Chlorhexidine is a clinically important antiseptic, disinfectant and preservative. It is a potent membrane-active agent against bacteria and inhibits outgrowth, but not germination, of bacterial spores, although it is not sporicidal. It shows high activity against wild-type and outer membrane mutants of Escherichia coli but some gram-negative bacteria are resistant to chlorhexidine by mechanisms not yet fully understood, although they appear to involve the outer, rather than the inner, membrane.
洗必泰是一种临床上重要的防腐剂、消毒剂和防腐剂。它是一种对细菌有强效膜活性的药剂,可抑制细菌芽孢的生长,但不抑制其萌发,尽管它没有杀孢子作用。它对大肠杆菌的野生型和外膜突变体具有高活性,但一些革兰氏阴性菌对洗必泰具有抗性,其机制尚未完全了解,尽管这些机制似乎涉及外膜而非内膜。