“离恶行善”：将Axl从失控的致癌基因转变为胰腺癌早期检测的生物标志物。
"Depart from evil, and do good": Turning Axl from uncontrolled tumorigenic gene to biomarker for early detection of pancreatic cancer.
作者信息
Comandatore Annalisa, Balsano Rita, Immordino Benoit, Arguedas Davinia, Capula Mjriam, Baglio Serena R, Garajovà Ingrid, Malapelle Umberto, Morelli Luca, Giovannetti Elisa
机构信息
Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HV Amsterdam, The Netherlands; General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56100 Pisa, Italy.
Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HV Amsterdam, The Netherlands; Medical Oncology Unit, University Hospital of Parma, 43100 , Italy.
出版信息
Crit Rev Oncol Hematol. 2022 May;173:103659. doi: 10.1016/j.critrevonc.2022.103659. Epub 2022 Apr 6.
Attempts to achieve early diagnosis are crucial to improve the outcome of patients with pancreatic ductal adenocarcinoma (PDAC). Here we present a critical evaluation of a recent study unraveling the potential of circulating AXL as a novel blood marker for early detection of PDAC and differential diagnosis from chronic pancreatitis (CP).
实现早期诊断对于改善胰腺导管腺癌（PDAC）患者的预后至关重要。在此，我们对一项近期研究进行批判性评估，该研究揭示了循环AXL作为一种新型血液标志物在PDAC早期检测及与慢性胰腺炎（CP）鉴别诊断中的潜力。
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