Engelberg I S, Ronnen M, Suster S, Schewach-Millet M, Stempler D, Schibi-Brilliant G
Int J Dermatol. 1986 Nov;25(9):606-7. doi: 10.1111/j.1365-4362.1986.tb04714.x.
The effects of treatment and depths of penetration of a 5-fluorouracil and salicylic acid preparation (Solcoderm) were studied in 24 patients treated for basal cell carcinoma with this compound. Two thirds of the patients in our study showed islands of residual tumor in the dermis following treatment, whereas total disappearance of the tumor was observed in one third. The depth of the fibrotic changes induced by the drug varied from 0.34 to 0.40 cm for the morphea type of basal cell carcinoma and from 0.52 to 0.88 cm for the conventional types. It is recommended that treatment with this compound be reserved only for superficial basal cell carcinomas and that it be avoided altogether in basal cell carcinomas of the morphea type.
在24例使用5-氟尿嘧啶和水杨酸制剂（索科尔德姆）治疗基底细胞癌的患者中，研究了该制剂的治疗效果及渗透深度。在我们的研究中，三分之二的患者在治疗后真皮层出现残留肿瘤岛，而三分之一的患者肿瘤完全消失。对于硬斑病型基底细胞癌，药物诱导的纤维化变化深度为0.34至0.40厘米，对于传统型基底细胞癌，该深度为0.52至0.88厘米。建议该化合物仅用于治疗浅表性基底细胞癌，应完全避免用于硬斑病型基底细胞癌。
