静脉血用于分析感染性休克模型中的酸碱状态。
Venous blood for the analysis of acid-base status in a model of septic shock.
机构信息
Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.
出版信息
Emerg Med Australas. 2022 Jun;34(3):456-458. doi: 10.1111/1742-6723.13975. Epub 2022 Apr 9.
OBJECTIVE
To determine the relationship between arterial and venous acid-base status in a model of septic shock.
METHODS
Paired samples (n = 435) of arterial and femoral venous blood from 57 sheep (47 septic, 10 non-septic) managed with protocol-guided ventilation, sedation, parenteral fluids and inotropic support.
RESULTS
The arterial-venous difference in acid-base parameters was similar with and without sepsis. There was a consistent arterio-venous relationship for metabolic (pH, lactate, bicarbonate, base excess), but not respiratory parameters (partial pressures of oxygen, carbon dioxide, and haemoglobin-oxygen saturation), independent of sepsis.
CONCLUSIONS
Venous blood provides a reliable measure of metabolic but not respiratory disturbance.
目的
在脓毒性休克模型中确定动脉和静脉酸碱状态之间的关系。
方法
对接受协议指导的通气、镇静、静脉补液和正性肌力支持治疗的 57 只绵羊（47 只脓毒症，10 只非脓毒症）的配对动脉和股静脉血样（n=435）进行检测。
结果
有无脓毒症时，酸碱参数的动脉-静脉差值相似。代谢（pH 值、乳酸、碳酸氢盐、碱剩余）参数具有一致的动静脉关系，但与脓毒症无关的呼吸（氧分压、二氧化碳分压和血红蛋白-氧饱和度）参数没有这种关系。
结论
静脉血可可靠地测量代谢紊乱，但不能测量呼吸紊乱。
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