实验性和移植补偿性糖尿病大鼠脑结构中的血清素和去甲肾上腺素含量
Serotonin and norepinephrine content in brain structures of rats with experimental and transplantation-compensated diabetes.
作者信息
Kulikov A V, Arkhipova L V, Tretyak T M, Bragin A G
出版信息
J Hirnforsch. 1986;27(5):495-9.
The development of alloxan-induced diabetes in rats is shown to be accompanied by a decrease in the norepinephrine (NE) and serotonin (5-OT) content in the neocortex and caudal segment of the brain stem. Simultaneously the intensity of 3H-leucine labelling of the brain tissue was decreased. The attempt to compensate the diabetic syndrome in rats by transplanting the embryonic pancreas (EP) into the anterior chamber of the eye (ACE) was successful. All the animals with the adapted transplant showed a return of the monoamine level to the normal, a decrease in urine glucose, as well as normalization of protein synthesis by the 14th-20th days.
研究表明，大鼠中由四氧嘧啶诱导的糖尿病发展过程伴随着大脑新皮质和脑干尾段中去甲肾上腺素（NE）和5-羟色胺（5-OT）含量的降低。同时，脑组织的3H-亮氨酸标记强度也降低。将胚胎胰腺（EP）移植到大鼠眼前房（ACE）以补偿糖尿病综合征的尝试取得成功。到第14 - 20天时，所有移植适应后的动物单胺水平恢复正常，尿糖降低，蛋白质合成也恢复正常。
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