Fuentes Ileana, Morishita Yoshikazu, Gonzalez-Salinas Sofia, Champagne Frances A, Uchida Shusaku, Shumyatsky Gleb P
Department of Genetics, Rutgers University, Piscataway, NJ, United States.
Department of Psychology, University of Texas at Austin, Austin, TX, United States.
Front Mol Neurosci. 2022 Mar 24;15:844295. doi: 10.3389/fnmol.2022.844295. eCollection 2022.
Maternal behavior is shaped and challenged by the changing developmental needs of offspring and a broad range of environmental factors, with evidence indicating that the maternal brain exhibits a high degree of plasticity. This plasticity is displayed within cellular and molecular systems, including both intra- and intercellular signaling processes as well as transcriptional profiles. This experience-associated plasticity may have significant overlap with the mechanisms controlling memory processes, in particular those that are activity-dependent. While a significant body of work has identified various molecules and intracellular processes regulating maternal care, the role of activity- and experience-dependent processes remains unclear. We discuss recent progress in studying activity-dependent changes occurring at the synapse, in the nucleus, and during the transport between these two structures in relation to maternal behavior. Several pre- and postsynaptic molecules as well as transcription factors have been found to be critical in these processes. This role reflects the principal importance of the molecular and cellular mechanisms of memory formation to maternal and other behavioral adaptations.
母性行为受到后代不断变化的发育需求以及广泛环境因素的塑造和挑战，有证据表明母体大脑具有高度可塑性。这种可塑性表现在细胞和分子系统中，包括细胞内和细胞间的信号传导过程以及转录谱。这种与经验相关的可塑性可能与控制记忆过程的机制有显著重叠，特别是那些依赖活动的机制。虽然大量研究已经确定了调节母性关怀的各种分子和细胞内过程，但依赖活动和经验的过程的作用仍不清楚。我们讨论了最近在研究与母性行为相关的突触、细胞核以及这两个结构之间运输过程中发生的依赖活动的变化方面取得的进展。已经发现几种突触前和突触后分子以及转录因子在这些过程中至关重要。这一作用反映了记忆形成的分子和细胞机制对母性行为及其他行为适应的主要重要性。
