Hamid M, Touarsa F, Satte A, Bourazza A
Department of Neurology, Mohammed V Military Instruction Hospital, Rabat Morocco.
Department of Radiology, Avicenna University Hospital, Rabat Morocco.
Radiol Case Rep. 2022 Apr 4;17(6):1870-1873. doi: 10.1016/j.radcr.2022.03.028. eCollection 2022 Jun.
Paget's disease of bone (PDB) is a progressive monostotic or polyostotic osteopathy with unknown cause. It is associated with the involvement of the nervous system. The cranial nerves, spinal roots, cauda equina, spinal cord, and brain can be affected in PDB due to their close anatomical relation to bone. Hearing loss occurs in 12%-50% of patients with PDB. The optic nerve can be affected at the optic canal. The diagnosis of PDB is radiological by highlighting characteristic lesions like thickening of the cortical bone, hypertrophic and fibrillary bones. Progressive or chronic neurological deficits should be treated with bisphosphonates. We present a rare case of multiple cranial nerve palsies as the first manifestation of PDB.
骨佩吉特病（PDB）是一种病因不明的进行性单骨或多骨骨病。它与神经系统受累有关。由于颅神经、脊神经根、马尾、脊髓和脑与骨骼的解剖关系密切，在PDB中可受到影响。12% - 50%的PDB患者会出现听力丧失。视神经在视神经管处可受到影响。PDB的诊断通过影像学检查突出显示特征性病变，如皮质骨增厚、肥大性和纤维性骨。进行性或慢性神经功能缺损应以双膦酸盐治疗。我们报告一例罕见的以多发性颅神经麻痹为PDB首发表现的病例。
