Wallace E, Wong J, Reid I R
Department of Medicine, University of Auckland, New Zealand.
Arch Intern Med. 1995 Sep 11;155(16):1813-5.
Spinal stenosis is a serious complication of Paget's disease of bone. Surgical decompression has a high complication rate and is not always effective. Medical therapy with bisphosphonates is established treatment in other forms of Paget's disease. To our knowledge, this is the first report of the use of intravenous pamidronate disodium as the sole treatment of lower limb weakness attributable to pagetic spinal stenosis. Our patient has been restored to independent living and has maintained his remission, with repeated treatment, for more than 5 years.
脊柱狭窄是佩吉特骨病的一种严重并发症。手术减压并发症发生率高，且并非总是有效。双膦酸盐药物治疗是佩吉特病其他形式的既定治疗方法。据我们所知，这是首次报道使用静脉注射帕米膦酸二钠作为治疗佩吉特氏脊柱狭窄所致下肢无力的唯一疗法。我们的患者已恢复独立生活，并通过反复治疗维持缓解状态超过5年。
