Key Laboratory for Aging and Regenerative Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China.
Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing 400042, China.
Oxid Med Cell Longev. 2022 Mar 31;2022:8986287. doi: 10.1155/2022/8986287. eCollection 2022.
The traditional Chinese medicine (commonly called "Tianma" in Chinese) has been widely used in the treatment of rheumatism, epilepsy, paralysis, headache, and dizziness. Phenolic compounds, such as gastrodin, -hydroxybenzyl alcohol (HBA), -hydroxybenzaldehyde, and vanillin are the main bioactive components isolated from . These compounds not only are structurally related but also share similar pharmacological activities, such as antioxidative and anti-inflammatory activities, and effects on the treatment of aging-related diseases. Here, we investigated the effect of -hydroxybenzyl alcohol (HBA) on neurodegenerative diseases and aging in models of (). Our results showed that HBA effectively delayed the progression of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease in models of . In addition, HBA could increase the average lifespan of N2 worms by more than 25% and significantly improve the age-related physiological functions of worms. Moreover, HBA improved the survival rate of worms under stresses of oxidation, heat, and pathogenic bacteria. Further mechanistic investigation revealed that HBA could activate FOXO/DAF-16 and SKN-1 to regulate antioxidative and xenobiotic metabolism pathway. HBA could also activate HSF-1 to regulate proteostasis maintenance pathway, mitochondrial unfolded stress response, endoplasmic stress response and autophagy pathways. The above results suggest that HBA activated multiple cellular protective pathways to increase stress resistance and protect against aging and aging-related diseases. Overall, our study indicates that HBA is a potential candidate for future development of antiaging pharmaceutical application.
天麻是一种传统中药（在中国通常被称为“天麻”），已广泛用于治疗风湿、癫痫、瘫痪、头痛和头晕等疾病。从天麻中分离得到的主要生物活性成分是酚类化合物，如天麻素、-羟基苯甲醇（HBA）、-羟基苯甲醛和香草醛。这些化合物不仅在结构上相关，而且具有相似的药理活性，如抗氧化和抗炎活性，以及对治疗与衰老相关疾病的作用。在这里，我们研究了 -羟基苯甲醇（HBA）对 （）模型中神经退行性疾病和衰老的影响。我们的结果表明，HBA 能有效延缓阿尔茨海默病、帕金森病和亨廷顿病等神经退行性疾病模型的进展。此外，HBA 能使 N2 线虫的平均寿命延长 25%以上，并显著改善线虫的与年龄相关的生理功能。此外，HBA 能提高线虫在氧化、热和致病菌应激下的存活率。进一步的机制研究表明，HBA 能激活 FOXO/DAF-16 和 SKN-1 来调节抗氧化和外来化合物代谢途径。HBA 还能激活 HSF-1 来调节蛋白质稳态维持途径、线粒体未折叠应激反应、内质网应激反应和自噬途径。上述结果表明，HBA 通过激活多种细胞保护途径来提高应激抗性，预防衰老和衰老相关疾病。总的来说，我们的研究表明 HBA 是未来抗衰老药物应用开发的潜在候选药物。
