Wothe Jillian K, Bergman Zachary R, Lofrano Arianna E, Doucette Melissa, Saavedra-Romero Ramiro, Prekker Matthew E, Lusczek Elizabeth R, Brunsvold Melissa E
Medical School, University of Minnesota, Minneapolis, MN, USA.
Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
Crit Care Res Pract. 2022 Apr 6;2022:2773980. doi: 10.1155/2022/2773980. eCollection 2022.
In this study, we evaluate the previously reported novel Minnesota Score for association with in-hospital mortality and allocation of venovenous extracorporeal membrane oxygenation in patients with acute respiratory distress syndrome with or without SARS-CoV-2 pneumonia.
This was a retrospective cohort study across four extracorporeal membrane oxygenation centers in Minnesota. Logistic regression was used to assess the relationship between the scores and in-hospital mortality, duration of ECMO cannulation, and discharge disposition. Priority groups were established statistically by maximizing the sum of sensitivity and specificity and compared to the previous qualitatively established priority groups.
Of 124 patients included in the study, 38% were treated for COVID-19 acute respiratory distress syndrome. The median age was 48 years, and 73% were male. The in-hospital mortality rate was 38%. The Minnesota Score was significantly associated with in-hospital mortality only (OR 1.13, =0.02). Statistically determined cut points were similar to qualitative cut points. SARS-CoV-2 status did not change the findings.
In our patient cohort, the Minnesota Score is associated with increased mortality. With further validation, proposed priority groups could be utilized for allocation of ECMO in times of increasing scarcity.
在本研究中，我们评估先前报道的新型明尼苏达评分与合并或不合并SARS-CoV-2肺炎的急性呼吸窘迫综合征患者的院内死亡率及静脉-静脉体外膜肺氧合分配之间的关联。
这是一项针对明尼苏达州四个体外膜肺氧合中心的回顾性队列研究。采用逻辑回归评估评分与院内死亡率、体外膜肺氧合插管持续时间及出院处置之间的关系。通过最大化敏感性和特异性之和，统计学确定优先组，并与先前定性确定的优先组进行比较。
在纳入研究的124例患者中，38%接受了COVID-19急性呼吸窘迫综合征治疗。中位年龄为48岁，73%为男性。院内死亡率为38%。明尼苏达评分仅与院内死亡率显著相关（比值比1.13，P=0.02）。统计学确定的切点与定性切点相似。SARS-CoV-2状态并未改变研究结果。
在我们的患者队列中，明尼苏达评分与死亡率增加相关。经过进一步验证后，在资源日益稀缺的情况下，建议的优先组可用于体外膜肺氧合的分配。
