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长链非编码RNA HOXC-AS3通过海绵化miR-216调控F11R表达促进胶质瘤进展。

The Long Non-Coding RNA HOXC-AS3 Promotes Glioma Progression by Sponging miR-216 to Regulate F11R Expression.

作者信息

Li Yongshuai, Peng Lu, Cao Xianwen, Yang Kun, Wang Zhen, Xiao Yong, Xiao Hong, Qian Chunfa, Liu Hongyi

机构信息

Department of Neurosurgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.

Department of Clinical Laboratory, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.

出版信息

Front Oncol. 2022 Mar 23;12:845009. doi: 10.3389/fonc.2022.845009. eCollection 2022.

DOI:10.3389/fonc.2022.845009
PMID:35402226
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8984117/
Abstract

HOXC cluster antisense RNA 3 (HOXC-AS3) is a long noncoding RNA (lncRNA) that plays a crucial role in various tumors; nevertheless, its role in glioma and its mechanism have not been completely elucidated. In this research, we discovered that HOXC-AS3 was over-expression in glioma cells and tissues and was associated with prognosis. Next, we determined that HOXC-AS3 targeted miR-216 as a sponge and that the F11 receptor (F11R) was the target of miR-216 by online databases analysis, qRT-PCR, and luciferase reporter assay. In addition, the rescue experiments confirmed that HOXC-AS3 regulated the expression of F11R by competitively binding miR-216 and functioning as a competing endogenous RNA (ceRNA). The intracranial glioblastoma mouse model suggested that HOXC-AS3 could promote glioma malignant progression . In summary, our study shows that the HOXC-AS3/miR-216/F11R axis plays an important role in the malignant progression of glioma, and may provide new ideas for the treatment of glioma.

摘要

HOXC簇反义RNA 3（HOXC-AS3）是一种长链非编码RNA（lncRNA），在多种肿瘤中发挥关键作用；然而，其在胶质瘤中的作用及其机制尚未完全阐明。在本研究中，我们发现HOXC-AS3在胶质瘤细胞和组织中高表达，且与预后相关。接下来，通过在线数据库分析、qRT-PCR和荧光素酶报告基因检测，我们确定HOXC-AS3作为海绵靶向miR-216，且F11受体（F11R）是miR-216的靶标。此外，拯救实验证实HOXC-AS3通过竞争性结合miR-216并作为竞争性内源RNA（ceRNA）发挥作用，从而调节F11R的表达。颅内胶质母细胞瘤小鼠模型表明HOXC-AS3可促进胶质瘤的恶性进展。总之，我们的研究表明HOXC-AS3/miR-216/F11R轴在胶质瘤的恶性进展中起重要作用，可能为胶质瘤的治疗提供新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/479f40b217f1/fonc-12-845009-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/7112a0219710/fonc-12-845009-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/9fbb1b91ca6f/fonc-12-845009-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/54f1bb8f0a7a/fonc-12-845009-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/b2c70a8d170c/fonc-12-845009-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/479f40b217f1/fonc-12-845009-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/7112a0219710/fonc-12-845009-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/5267b9edb3b9/fonc-12-845009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/9fbb1b91ca6f/fonc-12-845009-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/54f1bb8f0a7a/fonc-12-845009-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/b2c70a8d170c/fonc-12-845009-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/8984117/479f40b217f1/fonc-12-845009-g006.jpg

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