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HOXC簇反义RNA 3，一种新型长链非编码RNA，作为人类恶性肿瘤中的肿瘤生物标志物和治疗靶点。

HOXC Cluster Antisense RNA 3, a Novel Long Non-Coding RNA as an Oncological Biomarker and Therapeutic Target in Human Malignancies.

作者信息

Xie Yunhe, Ye Jiarong, Luo Hongliang

机构信息

Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330008, People's Republic of China.

Department of General Surgery, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, Jiangxi, 332007, People's Republic of China.

出版信息

Onco Targets Ther. 2023 Oct 24;16:849-865. doi: 10.2147/OTT.S425523. eCollection 2023.

DOI:10.2147/OTT.S425523
PMID:37899986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10612484/
Abstract

HOXC cluster antisense RNA 3 (HOXC-AS3) is a novel long noncoding RNA (lncRNA) that exhibits aberrant expression patterns in various cancer types. Its expression is closely related to clinicopathological features, demonstrating significant clinical relevance across multiple tumors. And HOXC-AS3 plays multifaceted roles in tumor progression, impacting cell proliferation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT), autophagy, senescence, tumor growth, and metastasis. In this review, we summarized and comprehensively analyzed the expression and clinical significance of HOXC-AS3 as a diagnostic and prognostic biomarker for malignancies. Additionally, we presented an in-depth update on HOXC-AS3's functions and regulatory mechanisms in cancer pathogenesis. This narrative review underscores the importance of HOXC-AS3 as a promising lncRNA candidate in cancer research and its potential as a predictive biomarker and therapeutic target in clinical applications.

摘要

HOXC簇反义RNA 3（HOXC-AS3）是一种新型长链非编码RNA（lncRNA），在多种癌症类型中呈现异常表达模式。其表达与临床病理特征密切相关，在多种肿瘤中显示出显著的临床相关性。并且HOXC-AS3在肿瘤进展中发挥多方面作用，影响细胞增殖、凋亡、迁移、侵袭、上皮-间质转化（EMT）、自噬、衰老、肿瘤生长和转移。在本综述中，我们总结并全面分析了HOXC-AS3作为恶性肿瘤诊断和预后生物标志物的表达及临床意义。此外，我们深入更新了HOXC-AS3在癌症发病机制中的功能和调控机制。这篇叙述性综述强调了HOXC-AS3作为癌症研究中一个有前景的lncRNA候选物的重要性及其在临床应用中作为预测性生物标志物和治疗靶点的潜力。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/836f/10612484/969d8a79fd47/OTT-16-849-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/836f/10612484/4ffd89a201e0/OTT-16-849-g0008.jpg

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