Mian Shan Yasin, Nambiar Abhishek, Kaliaperumal Chandrasekaran
Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Front Surg. 2022 Mar 25;9:844993. doi: 10.3389/fsurg.2022.844993. eCollection 2022.
Phytotherapy; the study of extracts of natural origin in the treatment of disease, has scarcely been applied in the management of GBM. A body of literature exists studying , the use of natural extracts against GBM cells. Given persisting poor prognoses, we evaluated, through systematic literature-review the therapeutic potential of naturally sourced extracts .
Using OVID, MEDLINE and EMBASE databases were searched with compound search term. Abstracts and full-texts were double-screened by independent reviewers.
Nine hundred and eighty-seven articles, excluding duplicated were screened, leading to the inclusion of 14. Amongst murine studies, Ashwagandha, Coptis Chinensis and Fructus Ligustri Lucidi in unprocessed forms, produced significant reductions in tumour volume. Amongst human studies, Perrilyl alcohol, derived from Lavender, reduced angiogenic cytokines in 31% of subjects, halted 6 month disease progression in 48.2% of subjects, and improved mean survival by 4.9 months in separate studies, respectively.
Although cursory, current trends in literature demonstrate the value of inhaled Lavender extract in the treatment of GBM, offering tangible clinical benefit to patients receiving conventional treatments. Furthermore, the administration of 8, discrete extracts in mice to produce significant responses in survival and tumour volume, suggest there is further scope for study. Although additional safety tests are required, currently, phytotherapeutics are the crossover to clinical translation, and additional trials are warranted to expound upon thus far promising results.
植物疗法，即研究天然提取物在疾病治疗中的应用，在胶质母细胞瘤（GBM）的管理中几乎未得到应用。已有大量文献研究天然提取物对GBM细胞的作用。鉴于预后仍然不佳，我们通过系统的文献综述评估了天然来源提取物的治疗潜力。
使用OVID、MEDLINE和EMBASE数据库，通过复合检索词进行检索。摘要和全文由独立评审员进行双盲筛选。
共筛选了987篇文章（排除重复文章），最终纳入14篇。在小鼠研究中，未加工形式的印度人参、黄连和女贞子可显著降低肿瘤体积。在人体研究中，薰衣草衍生的紫苏醇在31%的受试者中降低了血管生成细胞因子，在48.2%的受试者中使疾病进展停止6个月，在单独的研究中分别使平均生存期延长4.9个月。
尽管只是初步研究，但当前文献趋势表明吸入薰衣草提取物在治疗GBM方面具有价值，可为接受传统治疗的患者带来切实的临床益处。此外，在小鼠中给予8种不同提取物可在生存期和肿瘤体积方面产生显著反应，这表明还有进一步的研究空间。尽管还需要进行额外的安全性测试，但目前植物疗法正朝着临床转化迈进，有必要进行更多试验以阐明目前颇具前景的结果。
