四种呋喃香豆素：白芷素、4,5'-二甲基白芷素、补骨脂素和8-甲基补骨脂素对V79中国仓鼠细胞的诱变活性。
Mutagenic activity of four furocoumarins: angelicin, 4,5'-dimethyl-angelicin, psoralen and 8-methyl-psoralen on V79 Chinese hamster cells.
作者信息
Babudri N, Pani B, Venturini S, Monti-Bragadin C
出版信息
J Environ Pathol Toxicol Oncol. 1986 Sep-Dec;7(1-2):123-9.
Four furocoumarins, two having a linear structure (psoralen and 8-methyl-psoralen) and two having an angular structure (angelicin and 4,5'-dimethyl-angelicin), were studied for their mutagenic activity in the HGPRT system on V79 chinese hamster cells in culture (V79/HGPRT system). All the four drugs, when activated by near-ultraviolet (NUV) light, were effective in inducing HGPRT mutants. Their efficiency ranked in the following order: 8-methyl-psoralen greater than psoralen = 4,5-dimethylangelicin greater than angelicin.
研究了四种呋喃香豆素，其中两种具有线性结构（补骨脂素和8-甲基补骨脂素），两种具有角形结构（白芷素和4,5'-二甲基白芷素），考察它们在培养的V79中国仓鼠细胞的次黄嘌呤鸟嘌呤磷酸核糖转移酶（HGPRT）系统（V79/HGPRT系统）中的致突变活性。当用近紫外线（NUV）光激活时，所有这四种药物都能有效诱导HGPRT突变体。它们的效率按以下顺序排列：8-甲基补骨脂素＞补骨脂素 = 4,5-二甲基白芷素＞白芷素。
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