[光氧化呋喃香豆素对不饱和脂质和二羟基苯丙氨酸的暗氧化作用]
[Dark oxidation of unsaturated lipids and dihydroxy phenylalanine by photooxidized furocoumarins].
作者信息
Sukhorukov V L, Potanenko A Ia, Zakharova V A
出版信息
Vopr Med Khim. 1983 Sep-Oct;29(5):75-8.
Well-known skin photosensitizers furocoumarins--psoralen, angelio in and 8-methoxypsoralen were shown to photosensitize oxidation of unsaturated lipids and dihydroxyphenylalanine via a two-step mechanism. At the first step (UV-irradiation at 366 nm) photooxidation of furocoumarins occurred, at the second step--the photooxidized furocoumarins oxidized unsaturated lipids or dihydroxyphenylalanine in darkness. The photochemical activity of furocoumarins in the two-step reaction decreased as follows: psoralen greater than angelicin greater than 8-methoxypsoralen. Similar photoreactions appear to participate in induction of phototoxic effects of furocoumarins.
众所周知的皮肤光敏剂呋喃香豆素——补骨脂素、白芷素和8-甲氧基补骨脂素，通过两步机制使不饱和脂质和二羟基苯丙氨酸发生光氧化作用。第一步（366nm紫外线照射），呋喃香豆素发生光氧化；第二步——光氧化的呋喃香豆素在黑暗中氧化不饱和脂质或二羟基苯丙氨酸。呋喃香豆素在两步反应中的光化学活性降低顺序如下：补骨脂素＞白芷素＞8-甲氧基补骨脂素。类似的光反应似乎参与了呋喃香豆素光毒性效应的诱导过程。
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