DDIT4介导白细胞介素-34在人单核细胞白血病细胞中的促增殖作用。
DDIT4 mediates the proliferation-promotive effect of IL-34 in human monocytic leukemia cells.
作者信息
Lv Xiaoqian, Hu Yuting, Wang Lina, Zhang Dongyue, Wang Hao, Dai Yibo, Cui Xiaoxi, Zheng Guoguang
机构信息
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, China.
出版信息
Blood Sci. 2021 Apr 27;3(2):48-56. doi: 10.1097/BS9.0000000000000069. eCollection 2021 Apr.
IL-34 is involved in a broad range of cancer. that IL-34 promoted the proliferation and colony formation of human acute monocytic leukemia (AMoL) cells. However, the mechanism has not been elucidated. Here, by analyzing the gene profiles of Molm13 and THP1 cells overexpressing IL-34 , upregulation of the DNA damage-inducible transcript 4 (DDIT4) was detected in both series. Knockdown of DDIT4 cells. Our results suggest that DDIT4 mediates the proliferation-promotive effect of IL-34 whereas does not mediate the promotive effect of IL-34 on colony formation in AMoL cells.
白细胞介素-34（IL-34）参与多种癌症。有研究表明IL-34可促进人急性单核细胞白血病（AMoL）细胞的增殖和集落形成。然而，其机制尚未阐明。在此，通过分析过表达IL-34的Molm13和THP1细胞的基因谱，在这两个细胞系中均检测到DNA损伤诱导转录本4（DDIT4）的上调。敲低DDIT4细胞。我们的结果表明，DDIT4介导IL-34的促增殖作用，而不介导IL-34对AMoL细胞集落形成的促进作用。
Zotero 插件