Katsui Kuniaki, Ogata Takeshi, Sugiyama Soichi, Yoshio Kotaro, Kuroda Masahiro, Yamane Masaomi, Hiraki Takao, Kiura Katsuyuki, Toyooka Shinichi, Kanazawa Susumu
Department of Proton Beam Therapy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Department of Radiology, Iwakuni Clinical Center, Yamaguchi, Japan.
Cancer Diagn Progn. 2021 May 3;1(2):61-67. doi: 10.21873/cdp.10009. eCollection 2021 May-Jun.
To investigate whether muscle and adipose mass are associated with radiation pneumonitis (RP) in patients with non-small cell lung cancer undergoing preoperative concurrent chemoradiotherapy.
We calculated body mass index and determined skeletal muscle, psoas muscle, visceral adipose tissue (VAI), and subcutaneous adipose tissue indices, and visceral-to-subcutaneous adipose tissue area ratio for patients using computed tomography. We examined their relationship with grade 2 or more RP.
Among 94 patients, 28 experienced grade 2 or more RP. On multivariate analysis, only VAI was associated with grade 2 or more RP (all p=0.026). The 6-month incidence rates of grade 2 or more RP were 21.4% and 36.8% in patients with VAI <39 and ≥39 cm /m , respectively.
High visceral adipose mass is associated with grade 2 or more RP in patients undergoing preoperative concurrent chemoradiotherapy. Measuring visceral adipose mass may help to predict RP occurrence. Further studies are needed to validate our findings.
探讨接受术前同步放化疗的非小细胞肺癌患者的肌肉和脂肪量是否与放射性肺炎（RP）相关。
我们计算了体重指数，并使用计算机断层扫描确定了患者的骨骼肌、腰大肌、内脏脂肪组织（VAI）和皮下脂肪组织指数，以及内脏与皮下脂肪组织面积比。我们研究了它们与2级或更高级别RP的关系。
94例患者中，28例发生2级或更高级别RP。多因素分析显示，只有VAI与2级或更高级别RP相关（所有p=0.026）。VAI<39和≥39 cm²/m²的患者2级或更高级别RP的6个月发生率分别为21.4%和36.8%。
高内脏脂肪量与接受术前同步放化疗的患者2级或更高级别RP相关。测量内脏脂肪量可能有助于预测RP的发生。需要进一步研究来验证我们的发现。
