非小细胞肺癌患者中与免疫检查点抑制剂治疗相关的外周嗜酸性粒细胞数量和比例的绝对增加
Absolute Increase in the Number and Proportion of Peripheral Eosinophils Associated With Immune Checkpoint Inhibitor Treatment in Non-small Cell Lung Cancer Patients.
作者信息
Osawa Hajime, Shiozawa Toshihiro, Okauchi Shinichiro, Sasatani Yuika, Ohara Gen, Sato Shinya, Miyazaki Kunihiko, Kodama Takahide, Kagohashi Katsunori, Satoh Hiroaki, Hizawa Nobuyuki
机构信息
Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Mito, Japan.
出版信息
Cancer Diagn Progn. 2021 Nov 3;1(5):485-490. doi: 10.21873/cdp.10065. eCollection 2021 Nov-Dec.
BACKGROUND/AIM: To clarify the clinical significance of the absolute increase in the number and proportion of peripheral eosinophils associated with immune checkpoint inhibitor (ICPI) treatment in non-small cell lung cancer (NSCLC) patients.
PATIENTS AND METHODS
We performed a retrospective study, by reviewing the medical charts of 191 patients who were treated with ICPI monotherapy and 80 patients treated with the combination of ICPI and chemotherapy during the period from February 2016 and April 2021.
RESULTS
In patients treated with ICPI monotherapy, there was a significant difference in time to treatment failure (TTF) between the two groups divided by eosinophils ≥ or <10%. Similarly, a significant difference was found in TTF between the two groups divided by eosinophils ≥ or <1,500/μl. Factors related to both an increase in the number and percentage of peripheral eosinophils were "immune-related adverse effects (irAE) that did not lead to discontinuation of administration".
CONCLUSION
Some patients with irAE might have a 'favorable' absolute increase in peripheral eosinophils.
背景/目的：阐明非小细胞肺癌（NSCLC）患者中与免疫检查点抑制剂（ICPI）治疗相关的外周血嗜酸性粒细胞数量和比例的绝对增加的临床意义。
患者与方法
我们进行了一项回顾性研究，回顾了2016年2月至2021年4月期间接受ICPI单药治疗的191例患者和接受ICPI与化疗联合治疗的80例患者的病历。
结果
在接受ICPI单药治疗的患者中，根据嗜酸性粒细胞≥或<10%划分的两组之间的治疗失败时间（TTF）存在显著差异。同样，根据嗜酸性粒细胞≥或<1500/μl划分的两组之间的TTF也存在显著差异。与外周血嗜酸性粒细胞数量和百分比增加均相关的因素是“未导致给药中断的免疫相关不良反应（irAE）”。
结论
一些患有irAE的患者外周血嗜酸性粒细胞可能有“有利的”绝对增加。
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