Department of Food Science, Cornell University, Ithaca, New York, USA.
Nutrition and Health Department, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Crit Rev Food Sci Nutr. 2023;63(27):9017-9032. doi: 10.1080/10408398.2022.2060933. Epub 2022 Apr 9.
The benefits of dietary fiber on intestinal health have been well established. However, there is no consensus on the dietary fiber effects on mineral absorption. The objective of this systematic review is to discuss the evidence on the dietary fiber effects on iron absorption and iron status-related biomarkers. A comprehensive search of 3 databases: PubMed, Scopus and Web of Science was carried out. We followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, and a total of 32 studies were included with 9 of them clinical studies and 23 . The studies included assessment of dietary fiber in the form of fructo-oligosaccharides, galacto-oligosaccharides, inulin, pectin, guar gum, oligofructose, xylo-oligosaccharides, and mannan-oligosaccharide. Hemoglobin (n = 21) and fractional iron absorption (n = 6) were the most frequently reported outcomes. The results showed no significant correlations between consumption of dietary fiber to iron absorption/status-related biomarkers. However, the current evidence may not be substantial to invalidate the recommendation of dietary fiber as an agent to improve dietary iron bioavailability, and absorption. In conclusion, there is a need to conduct further clinical trials with long dietary fiber intervention focusing on population at high risk for iron deficiency.
膳食纤维对肠道健康的益处已得到充分证实。然而，对于膳食纤维对矿物质吸收的影响，目前尚未达成共识。本系统评价的目的是讨论膳食纤维对铁吸收和与铁状态相关的生物标志物的影响的证据。我们对 3 个数据库（PubMed、Scopus 和 Web of Science）进行了全面检索。我们遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南，共纳入了 32 项研究，其中 9 项为临床研究，23 项为非临床研究。这些研究评估了膳食纤维的形式，包括低聚果糖、半乳寡糖、菊粉、果胶、瓜尔胶、低聚果糖、木寡糖和甘露寡糖。血红蛋白（n=21）和铁吸收分数（n=6）是最常报告的结果。结果表明，膳食纤维的摄入量与铁吸收/状态相关生物标志物之间没有显著相关性。然而，目前的证据可能还不足以否定膳食纤维作为改善膳食铁生物利用度和吸收的一种手段的建议。总之，需要进行进一步的临床试验，对高缺铁风险人群进行长期膳食纤维干预，以解决这一问题。
