Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
J Vet Diagn Invest. 2022 May;34(3):564-567. doi: 10.1177/10406387221088596. Epub 2022 Apr 10.
Given its unusual lymphatic drainage system, the tonsil is a rare site of metastasis, with few reports in the human and veterinary literature. Prognosis in cases of tonsillar metastasis is reportedly poor. We describe here a unique case of urinary bladder urothelial carcinoma (UC) with metastasis to the tonsil in an 11-y-old, spayed female, mixed-breed dog. At presentation, the patient had a history of a growing neck mass and increasing lethargy, hyporexia, weight loss, drooling, and diarrhea for 2 wk. A carcinoma was diagnosed by cytology. Given the poor prognosis, the patient was euthanized. Postmortem examination revealed masses in the inguinal region, cranioventral neck region including tonsil, and urinary bladder. Histologically, the masses were composed of large polyhedral cells arranged in dense sheets and nests with occasional large, clear, intracytoplasmic vacuoles. Neoplastic cells were multifocally positive for uroplakin III and cytokeratin 8/18 by immunohistochemistry. UC with metastasis to tonsil and lymph nodes was diagnosed.
由于其独特的淋巴引流系统，扁桃体是转移的罕见部位，在人类和兽医文献中报道较少。扁桃体转移的预后据报道很差。我们在这里描述了一例罕见的 11 岁已绝育雌性混合品种犬的尿路上皮膀胱癌（UC）伴扁桃体转移的病例。就诊时，该患者有颈部长肿块且逐渐增大、嗜睡、食欲减退、体重减轻、流口水和腹泻 2 周的病史。细胞学诊断为癌。由于预后不良，对该患者实施了安乐死。尸检显示腹股沟区、颅腹颈区（包括扁桃体）和膀胱有肿块。组织学上，这些肿块由大而多角形的细胞排列成密集的片状和巢状，偶尔有大的、透明的、胞浆内空泡。免疫组织化学检查显示肿瘤细胞局灶性表达尿路上皮蛋白 III 和细胞角蛋白 8/18。诊断为伴有扁桃体和淋巴结转移的 UC。
