Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Department of Women's Health, University Women's Hospital and Research Centre for Women's Health, University of Tuebingen, Tuebingen, Germany.
Gynecol Endocrinol. 2022 Jun;38(6):523-527. doi: 10.1080/09513590.2022.2060961. Epub 2022 Apr 9.
(1) To characterize the cytokine expression profiles of endometriosis related infertile women in comparison to fertile women with endometriosis; (2) to investigate the correlation of the cytokine levels from different tissues.
100 stage IV endometriosis patients were recruited and grouped by infertility status ( = 50, separately). Concentrations of TNF-α, TGF-β1, IL-10, and IL-17A from the serum, peritoneal fluid (PF), eutopic, and ectopic endometrium samples were measured.
(1) In the infertile group, the concentrations of IL-10 within serum, PF and eutopic endometrium were all significantly higher ( = .022 and <.01, .013, respectively), the levels of TGF-β1 in serum and eutopic endometrium samples were both higher ( = .025 and < .01), the levels of IL-17A in the PF, eutopic, and ectopic endometrium were all lower ( < .01, all). (2) Significant positive correlation was observed between IL-17A from PF and the ectopic endometrium ( = .014), IL-17A from PF and eutopic endometrium ( < .01). The PF IL-10 levels positively correlated with those in the serum ( = .007).
This is the first study comparing the levels of cytokines within four different tissues of endometriosis women with or without infertility. The study revealed that endometriosis-related infertile women possess significant differences in cytokine levels in comparison to fertile women with endometriosis. The levels of inflammatory factors from different tissues had certain positive correlations. Infertility may indicate the progress of the disease.
（1）比较不孕和不孕合并不孕症患者的子宫内膜异位症相关患者的细胞因子表达谱；（2）研究不同组织中细胞因子水平的相关性。
招募 100 名 IV 期子宫内膜异位症患者，并根据不孕状况进行分组（ = 50，分别）。测量血清、腹腔液（PF）、在位和异位子宫内膜样本中 TNF-α、TGF-β1、IL-10 和 IL-17A 的浓度。
（1）在不孕组中，血清、PF 和在位子宫内膜中 IL-10 的浓度均明显升高（ = .022 和 <.01，.013，分别），血清和在位子宫内膜样本中的 TGF-β1 水平均升高（ = .025 和 < .01），PF、在位和异位子宫内膜中的 IL-17A 水平均降低（ < .01，均）。（2）PF 中的 IL-17A 与异位子宫内膜呈显著正相关（ = .014），PF 中的 IL-17A 与在位子宫内膜呈显著正相关（ < .01）。PF 的 IL-10 水平与血清中的水平呈正相关（ = .007）。
这是第一项比较子宫内膜异位症伴或不伴不孕的女性四种不同组织中细胞因子水平的研究。该研究表明，与不孕合并不孕症的子宫内膜异位症相关患者的细胞因子水平存在显著差异。来自不同组织的炎症因子之间存在一定的正相关。不孕可能表明疾病的进展。
