Iscan E, Karakülah G, Ekin U, Ozturk M, Uzuner H, Suner A
Izmir Biomedicine and Genome Center, Izmir, Turkey.
Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, 35330 Turkey.
Mol Biol (Mosk). 2022 Mar-Apr;56(2):320. doi: 10.31857/S0026898422020082.
The transcription factor p73 is a member of the p53 tumor suppressor gene family and one of the key regulators of apoptosis. TP73 gene encodes two protein isoforms classes with diverse functions, TAp73 and DNp73, and TAp73 expression in tumor tissues is altered. Unlike the TP53 gene, TP73 is not mutated in cancers. Here, we sought to explore the expression of p73 isoforms across eight major cancer types using the publicly available data deposited at the GDC data portal and the TSVdb database. Our results showed that TAp73α is overexpressed in breast invasive carcinoma, stomach adenocarcinoma, lung squamous cell carcinoma, colon adenocarcinoma, and esophageal carcinoma tumors, whereas the expression of DNp73 isoforms is downregulated in breast invasive carcinoma (DNp73α,β,γ), Prostate Adenocarcinoma (DNp73β), Lung Adenocarcinoma (DNp73α), Lung Squamous Cell Carcinoma (DNp73α) tumors. In summary, this study revealed that TAp73α has higher expression than the DNp73 isoforms in several cancer types.
转录因子p73是p53肿瘤抑制基因家族的成员之一，也是细胞凋亡的关键调节因子之一。TP73基因编码具有不同功能的两类蛋白质异构体，即TAp73和DNp73，并且肿瘤组织中TAp73的表达会发生改变。与TP53基因不同，TP73在癌症中不会发生突变。在此，我们试图利用存于GDC数据门户和TSVdb数据库中的公开数据，探究p73异构体在八种主要癌症类型中的表达情况。我们的结果显示，TAp73α在乳腺浸润癌、胃腺癌、肺鳞状细胞癌、结肠腺癌和食管癌肿瘤中过表达，而DNp73异构体在乳腺浸润癌（DNp73α、β、γ）、前列腺腺癌（DNp73β）、肺腺癌（DNp73α）、肺鳞状细胞癌（DNp73α）肿瘤中的表达下调。总之，本研究揭示了在几种癌症类型中TAp73α的表达高于DNp73异构体。
