Dermatology Department, Medicine Faculty, Sivas Cumhuriyet University, Sivas, Turkey.
J Cosmet Dermatol. 2022 Oct;21(10):5111-5115. doi: 10.1111/jocd.14984. Epub 2022 Apr 26.
Seborrheic dermatitis (SD) is a chronic inflammatory disease. The etiology of the disease is still unknown. The systemic immune-inflammation index (SII), red cell distribution width (RDW), mean platelet volume (MPV), C-reactive protein (CRP), monocyte to HDL cholesterol ratio (MHR), platelet to lymphocyte ratio (PLR), and neutrophil to lymphocyte ratio (NLR) have all been reported as inflammatory markers in recent studies. However, these inflammatory markers have not been explored in SD patients. This study aimed to explore inflammatory and hematological parameters in SD patients with healthy controls (HCs) and evaluate their possible relationship with disease severity.
One hundred patients who presented to our hospital were diagnosed with SD and 74 HCs were retrospectively included in our study. The seborrheic dermatitis area severity index (SDASI) score was used to assess the severity of the SD.
The patient group's mean PLR, MPV ve CRP levels were statistically significantly higher than the HCs (p < 0.05). There was no statistically significant difference in the patients compared with the control group regarding RDW, NLR, MHR, and SII levels (p > 0.05). There was no statistically significant correlation between NLR, PLR, MPV, monocyte/HDL cholesterol, SII levels with age, and SDASI in the patient group. There was a significant correlation between CRP with age and RDW with SDASI score.
Hematological parameters and CRP are low-cost tests. These tests can be used to define inflammation levels in inflammatory diseases. This study shows that PLR, CRP, and MPV may be used as novel inflammatory markers in SD.
脂溢性皮炎(SD)是一种慢性炎症性疾病。该病的病因尚不清楚。最近的研究报道,全身免疫炎症指数(SII)、红细胞分布宽度(RDW)、平均血小板体积(MPV)、C 反应蛋白(CRP)、单核细胞与高密度脂蛋白胆固醇比值(MHR)、血小板与淋巴细胞比值(PLR)和中性粒细胞与淋巴细胞比值(NLR)均为炎症标志物。然而,这些炎症标志物在 SD 患者中尚未得到探索。本研究旨在探讨 SD 患者与健康对照者(HCs)的炎症和血液学参数,并评估其与疾病严重程度的可能关系。
回顾性纳入 100 例我院就诊的 SD 患者和 74 例 HCs。采用脂溢性皮炎面积严重程度指数(SDASI)评分评估 SD 的严重程度。
患者组的平均 PLR、MPV 和 CRP 水平明显高于 HCs(p<0.05)。与对照组相比,患者组的 RDW、NLR、MHR 和 SII 水平无统计学差异(p>0.05)。在患者组中,NLR、PLR、MPV、单核细胞/HDL 胆固醇、SII 水平与年龄、SDASI 之间无统计学相关性。CRP 与年龄、RDW 与 SDASI 评分之间存在显著相关性。
血液学参数和 CRP 是低成本的检测方法。这些检测方法可用于定义炎症性疾病中的炎症水平。本研究表明,PLR、CRP 和 MPV 可能可作为 SD 的新型炎症标志物。