Department of Dermatology and Venereology, Health Sciences University Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
Eur Rev Med Pharmacol Sci. 2023 Oct;27(19):9267-9272. doi: 10.26355/eurrev_202310_33954.
We aimed to investigate the interrelation of HS with CBC parameters and new inflammatory indicator parameters, systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI).
102 patients diagnosed with HS and 99 healthy controls were included. The medical records and laboratory findings of the participants were reviewed retrospectively. Patients and control group neutrophil, lymphocyte, monocyte, and platelet counts, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), mean platelet volume (MPV), platelet distribution width (PDW) and red cell distribution width coefficient of variation (RDW), SII and SIRI were compared.
The patient and control groups differed significantly concerning CRP, neutrophil count, lymphocyte count, monocytes count, platelet count, PLR, and MHR (p<0.05), whereas the mean of MPV and NLR did not show a significant difference in control individuals. SII and SIRI were significantly higher in patients with HS than in controls (p=0.005, p<0.001). Correlation analyses of SII and SIRI with each other and CRP were performed. It was determined that SIRI had a moderate correlation with CRP (r=0. 346, p<0.001). The correlation between SII and CRP was low (r=0.256, p<0.001). In addition, we analyzed the correlation between SII and SIRI and we determined a high level of correlation (r=0.675, p<0.001).
Our study has objectively demonstrated that SII and SIRI are more reliable biomarkers than other inflammation parameters in HS patients. Thus, SII and SIRI would be used to evaluate treatment response and follow-up in HS as new indicators.
本研究旨在探讨 HS 与 CBC 参数以及新的炎症指标参数，包括全身免疫炎症指数（SII）和全身炎症反应指数（SIRI）之间的相互关系。
纳入了 102 例 HS 患者和 99 名健康对照者。回顾性分析了参与者的病历和实验室检查结果。比较了患者组和对照组的中性粒细胞、淋巴细胞、单核细胞和血小板计数、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）、平均血小板体积（MPV）、血小板分布宽度（PDW）和红细胞分布宽度变异系数（RDW）、SII 和 SIRI。
患者组和对照组在 CRP、中性粒细胞计数、淋巴细胞计数、单核细胞计数、血小板计数、PLR 和 MLR 方面存在显著差异（p<0.05），而对照组个体的 MPV 和 NLR 平均值没有显著差异。HS 患者的 SII 和 SIRI 明显高于对照组（p=0.005，p<0.001）。对 SII 和 SIRI 之间以及与 CRP 之间进行了相关性分析。结果表明，SIRI 与 CRP 中度相关（r=0.346，p<0.001）。SII 与 CRP 的相关性较低（r=0.256，p<0.001）。此外，我们分析了 SII 和 SIRI 之间的相关性，发现两者高度相关（r=0.675，p<0.001）。
我们的研究客观地表明，SII 和 SIRI 是 HS 患者比其他炎症参数更可靠的生物标志物。因此，SII 和 SIRI 将作为新指标用于评估 HS 的治疗反应和随访。
