Clinical Pharmacy Unit, Faculty of Pharmacy, 60605AIMST University, Bedong, Kedah, Malaysia.
Pharmacy Department, AU2 Taman Keramat Health Clinic, Kuala Lumpur, Malaysia.
Nutr Health. 2022 Dec;28(4):489-493. doi: 10.1177/02601060221089105. Epub 2022 Apr 11.
Obesity is a complex and multifactorial disease that is strongly associated with multiple comorbidities and mortality. Weight reduction in overweight and obese patients was highly desired to minimize future complications. Meal replacement is emerging as one of the effective tools to promote weight loss. Isoflavones and soy protein present in soybean are able to promote weight loss and alleviate obesity. Our systematic review aims to investigate the weight loss effect of soy-based meal replacement among the overweight and obese population. We will conduct a systematic review of RCTs that evaluated the effect of a soy-based meal replacement on weight loss in overweight and obese patients. The primary outcome of this review is weight loss. Besides that, we will assess BMI, body fat, waist circumference and hip circumference as the secondary outcome. We will search PubMed and the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library. Two reviewers will independently screen titles and abstracts, review full texts, extract information and assess the risk of bias of individual studies. We will conduct meta-analyses using a random-effect model if sufficient data are available. If meta-analysis is not performed, we will present a systematic qualitative synthesis. This systematic review will identify the weight loss effect of soy-based meal replacement among the overweight and obese adult population. We expect the result may strengthen the evidence on the role of soy-based meal replacement in optimal body weight management.
肥胖是一种复杂的多因素疾病，与多种合并症和死亡率密切相关。减轻超重和肥胖患者的体重是降低未来并发症风险的首要目标。代餐已成为促进体重减轻的有效手段之一。大豆中的异黄酮和大豆蛋白能够促进体重减轻和缓解肥胖。我们的系统评价旨在调查基于大豆的代餐在超重和肥胖人群中的减肥效果。我们将对评估基于大豆的代餐对超重和肥胖患者体重减轻效果的 RCT 进行系统评价。本综述的主要结局是体重减轻。此外，我们还将评估 BMI、体脂肪、腰围和臀围作为次要结局。我们将检索 PubMed 和 Cochrane 图书馆中的 Cochrane 中央对照试验注册库 (CENTRAL)。两名评审员将独立筛选标题和摘要、审查全文、提取信息并评估单个研究的偏倚风险。如果有足够的数据，我们将使用随机效应模型进行荟萃分析。如果不能进行荟萃分析，我们将进行系统定性综合。本系统评价将确定基于大豆的代餐在超重和肥胖成年人群中的减肥效果。我们希望研究结果能够加强基于大豆的代餐在最佳体重管理中的作用的证据。
