Sechenov First Moscow State Medical University, Tareev Clinic of Internal Diseases,. Rossolimo Moscow, Russia.
Lomonosov Moscow State University, Faculty of Medicine, Moscow, Russia.
Clin Hemorheol Microcirc. 2022;82(2):141-148. doi: 10.3233/CH-221391.
Nephrotic syndrome (NS) is associated with a high risk for venous and arterial thrombosis due to hypercoagulability. Integral tests designed to assess hemostasis can become an alternative for measuring hypercoagulability in patients with NS.
To assess hemostatic disorders in CGN patients complicated by NS using the thrombodynamics test.
The study included 60 adult patients with chronic glomerulonephritis (CGN), mean age 37 years, 31 (52%) women, and 29 (48%) men. Among all patients, 53 % of patients had NS, 47 % had no sign of NS. Hemostasis was assessed using the thrombodynamics test. The results were compared with biochemical parameters, which are usually associated with NS and renal dysfunction.
According to the thrombodynamics test, CGN patients with NS demonstrated a tendency to hypercoagulability: increased rates of V (rate of clot growth), increased D (clot density), and increased CS (clot size) after 30 minutes. A positive correlation of these parameters with the serum albumin, creatinine levels, and glomerular filtration rate (GFR) indicates the influence of severe NS and renal dysfunction on the hemostasis activation in CGN patients with NS.
According to the thrombodynamics test, CGN patients with NS demonstrate increased rates of clot formation, increased clot size after 30 minutes, and increased clot density due to secondary hemostasis activation. These changes positively correlate with the severity of hypoalbuminemia, hypercholesterolemia, and renal dysfunction in NS patients.
使用血栓动力学试验评估 CGN 患者并发 NS 时的止血异常。
本研究纳入 60 例成年 CGN 患者，平均年龄 37 岁，31 例（52%）为女性，29 例（48%）为男性。所有患者中，53%的患者存在 NS，47%的患者无 NS 表现。使用血栓动力学试验评估止血情况。将结果与通常与 NS 和肾功能障碍相关的生化参数进行比较。
根据血栓动力学试验，存在 NS 的 CGN 患者存在高凝倾向：30 分钟后 V 增加（血栓生长速度）、D 增加（血栓密度）和 CS 增加（血栓大小）。这些参数与血清白蛋白、肌酐水平和肾小球滤过率（GFR）呈正相关，表明严重 NS 和肾功能障碍对存在 NS 的 CGN 患者止血激活的影响。
根据血栓动力学试验，存在 NS 的 CGN 患者的血栓形成速度加快，30 分钟后的血栓大小增加，血栓密度增加，这是继发止血激活的结果。这些变化与 NS 患者低白蛋白血症、高胆固醇血症和肾功能障碍的严重程度呈正相关。
