结直肠癌中与肿瘤相关的 CD3 和 CD8 阳性免疫细胞：CD8+/CD3+ 比值的附加预后价值仍存在争议。
Tumor-associated CD3- and CD8-positive immune cells in colorectal cancer: The additional prognostic value of CD8+-to-CD3+ ratio remains debatable.
机构信息
Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
出版信息
Tumour Biol. 2022;44(1):37-52. doi: 10.3233/TUB-211571.
BACKGROUND
A large number of infiltrating CD3- and CD8-positive inflammatory cells indicates an improved survival in colorectal cancer (CRC), similar to many other cancers.
OBJECTIVE
We investigated the prognostic value of different combinations of CD3- and CD8-positive immune cells in CRC patients.
METHODS
The densities of CD3- and CD8-positive cells in intratumoral and stromal tissues were evaluated from 539 patients, for which we calculated a CD3 tumor-stroma index, a CD8 tumor-stroma index, and a CD3-CD8 tumor-stroma index.
RESULTS
High CD3 and CD8 tumor-stroma indices associated with stage I to II disease (p < 0.001 for both). The CD3 tumor-stroma index associated with a colonic tumor location (p = 0.006), while the CD8 tumor-stroma index associated with right-sided tumors (p < 0.001) and histological grade 3 tumors (p = 0.032). High intratumoral and stromal densities for CD3- and CD8-positive immune cells, the CD3 tumor-stroma index, the CD8 tumor-stroma index, and the CD3-CD8 tumor-stroma index all indicated a better DSS.
CONCLUSIONS
The CD3 tumor-stroma index carries a strong prognostic value in CRC, and none of the CD3 and CD8 combinations we analyzed proved superior.
背景
大量浸润的 CD3 和 CD8 阳性炎性细胞表明结直肠癌（CRC）的生存率提高，这与许多其他癌症相似。
目的
我们研究了 CRC 患者中不同 CD3 和 CD8 阳性免疫细胞组合的预后价值。
方法
从 539 名患者中评估了肿瘤内和基质组织中 CD3 和 CD8 阳性细胞的密度，我们计算了 CD3 肿瘤-基质指数、CD8 肿瘤-基质指数和 CD3-CD8 肿瘤-基质指数。
结果
高 CD3 和 CD8 肿瘤-基质指数与 I 期至 II 期疾病相关（两者均 p < 0.001）。CD3 肿瘤-基质指数与结肠肿瘤位置相关（p = 0.006），而 CD8 肿瘤-基质指数与右侧肿瘤（p < 0.001）和组织学 3 级肿瘤（p = 0.032）相关。CD3 和 CD8 阳性免疫细胞的肿瘤内和基质密度高、CD3 肿瘤-基质指数、CD8 肿瘤-基质指数和 CD3-CD8 肿瘤-基质指数均提示 DSS 较好。
结论
CD3 肿瘤-基质指数在 CRC 中具有很强的预后价值，我们分析的 CD3 和 CD8 组合均没有证明具有优越性。
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