Department of Chemistry, Tamkang University, New Taipei City, 251301, Taiwan (R.O.C.).
Department of Chemistry, National Tsing Hua University, Hsinchu, 300044, Taiwan (R.O.C.).
Org Lett. 2022 Apr 22;24(15):2915-2920. doi: 10.1021/acs.orglett.2c00920. Epub 2022 Apr 11.
Herein, we report the nickel-catalyzed denitrogenative cyclization reaction of 1,2,3,4-benzothiatriazine-1,1-dioxides with arynes to generate the polysubstituted biaryl sultams with tolerance of a wide diversity of substituents on every subunit. The mechanistic study indicates that the reaction is initiated by the formation of a diradical species, which reacts with a nickel complex to form a nickelacycle intermediate and carries out the subsequent cyclization through insertion of an aryne.
在此，我们报告了镍催化的 1,2,3,4-苯并噻二嗪-1,1-二氧化物与芳炔的脱氮环化反应，生成了具有高容忍度的多取代联芳基磺酰胺，每个亚基上都具有多种取代基。机理研究表明，反应是由双自由基物种的形成引发的，该物种与镍配合物反应形成镍杂环中间体，并通过芳炔的插入进行后续的环化反应。
