Küçük Ahmet, Bir Levent Sinan, Tekin Selma, Demir Süleyman
Department of Neurology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Department of Medical Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Horm Mol Biol Clin Investig. 2022 Apr 11;43(3):281-288. doi: 10.1515/hmbci-2021-0074. eCollection 2022 Sep 1.
Vitamin D is an important regulator of the immune system, and it has been shown that deficiency of vitamin D is significant environmental factor in some immune-mediated diseases such as Multiple Sclerosis (MS). In this study, we have compared serum 25 hydroxyvitamin (OH) D levels in Relapsing-Remitting Multiple Sclerosis (RRMS), clinically isolated syndrome (CIS), and control groups.
Forty patients with CIS and 60 patients who have been diagnosed RRMS between age 18-45, respectively, and followed up at Pamukkale University Faculty of Medicine, Department of Neurology, and 60 healthy individuals have been included in this study. Serum 25(OH) vitamin D, calcium, phosphorus, alkaline phosphatase, parathormone, insulin, and fasting blood glucose levels were studied for all three groups.
A statistically significant difference was determined in the comparison of three groups for mean 25(OH) vitamin D levels. In the intergroup comparison of mean 25(OH) vitamin D; mean 25(OH) vitamin D level was determined to be statistically significantly lower in both RRMS and CIS groups compared to control group (p<0.05).
Since vitamin D deficiency poses a problem from the early stage of disease spectrum in both CIS patients and MS patients, 25(OH) vitamin D level should be routinely controlled, and replacement should be administered upon any deficiency state.
维生素D是免疫系统的重要调节因子，已有研究表明，维生素D缺乏是多发性硬化症（MS）等一些免疫介导疾病的重要环境因素。在本研究中，我们比较了复发缓解型多发性硬化症（RRMS）、临床孤立综合征（CIS）和对照组的血清25-羟维生素（OH）D水平。
本研究纳入了40例CIS患者和60例年龄在18 - 45岁之间、在棉花堡大学医学院神经科随访的RRMS患者，以及60名健康个体。对三组患者均检测血清25(OH)维生素D、钙、磷、碱性磷酸酶、甲状旁腺激素、胰岛素和空腹血糖水平。
三组患者的平均25(OH)维生素D水平比较存在统计学显著差异。在平均25(OH)维生素D的组间比较中，RRMS组和CIS组的平均25(OH)维生素D水平均显著低于对照组（p<0.05）。
由于维生素D缺乏在CIS患者和MS患者疾病谱的早期阶段就构成问题，应常规检测25(OH)维生素D水平，一旦出现缺乏状态就应进行补充。
