Ferreira R C, Ferreira L C
Mem Inst Oswaldo Cruz. 1986 Jan-Mar;81(1):49-52. doi: 10.1590/s0074-02761986000100006.
The nitroimidazole-tiadiazole derivative CL 64,855 (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole, a potent anti-trypanosomal drug, was assayed in a short-term bacterial mutagenicity test with Salmonella typhimurium strains TA 98, TA 100 and TA 102. Results indicate that CL 64,855 is a potent frameshift mutagen detected by strains TA 98 and TA 102. CL 64,855 was able to revert the indicators strains at concentrations as low as 0.1 micrograms/plate. Metabolic activation experiments with rat liver microsomal fractions did not increase the mutagenic action of CL 64,855.
硝基咪唑-噻二唑衍生物CL 64,855（2-氨基-5-（1-甲基-5-硝基-2-咪唑基）-1,3,4-噻二唑）是一种强效抗锥虫药物，使用鼠伤寒沙门氏菌TA 98、TA 100和TA 102菌株进行了短期细菌致突变性试验。结果表明，CL 64,855是一种强效移码诱变剂，可被TA 98和TA 102菌株检测到。CL 64,855在低至0.1微克/平板的浓度下就能使指示菌株回复突变。用大鼠肝微粒体组分进行的代谢活化实验并未增强CL 64,855的诱变作用。
