Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/3, 90-236 Lodz, Poland.
Nutrients. 2022 Mar 26;14(7):1390. doi: 10.3390/nu14071390.
Patients affected by coronavirus disease 2019 (COVID-19) demonstrate a range of hemostasis dysfunctions, such as coagulation dysfunction and changes in blood platelet function, this being a major cause of death. These complications may also be associated with oxidative stress. Recently, various papers, including some reviews, have suggested that the use of dietary bioactive compounds, including phenolic compounds, may play a significant role in the treatment of COVID-19. However, while some phenolic compounds, such as curcumin, resveratrol, myricetin and scutellarian, have been found to have antiviral effects against COVID-19, recommendations regarding the use of such compounds to prevent or reduce the risk of CVDs during COVID-19 infection remain tentative. The present mini-review examines the antioxidant, anti-platelet and anticoagulant and antiviral activities of selected phenolic compounds and the possible implications for their use in treating CVDs associated with COVID-19. This review also examines whether these phenolic compounds can be promising agents in the modulation of hemostasis and CVDs during COVID-19. While their properties have been well documented in various in vitro and in vivo studies, particularly their positive role in the prophylaxis and treatment of CVDs, less is known regarding their prophylactic potential against CVDs during COVID-19, and no credible evidence exists for their efficiency in humans or animals. In such cases, no in vitro or in vivo studies are available. Therefore, it cannot be unequivocally stated whether treatment with these phenolic compounds offers benefits against CVDs in patients with COVID-19.
受 2019 年冠状病毒病 (COVID-19) 影响的患者表现出一系列止血功能障碍，如凝血功能障碍和血小板功能改变，这是主要的死亡原因。这些并发症也可能与氧化应激有关。最近，包括一些综述在内的各种论文表明，膳食生物活性化合物（包括酚类化合物）的使用可能在 COVID-19 的治疗中发挥重要作用。然而，虽然一些酚类化合物，如姜黄素、白藜芦醇、杨梅素和半枝莲，已被发现具有抗 COVID-19 的抗病毒作用，但关于使用这些化合物来预防或降低 COVID-19 感染期间 CVD 风险的建议仍不确定。本小型综述检查了选定酚类化合物的抗氧化、抗血小板、抗凝和抗病毒活性，以及它们在治疗与 COVID-19 相关的 CVD 中的可能应用。本综述还检查了这些酚类化合物是否可以成为调节 COVID-19 期间止血和 CVD 的有前途的药物。虽然它们的特性在各种体外和体内研究中得到了很好的记录，特别是它们在预防和治疗 CVD 方面的积极作用，但关于它们在 COVID-19 期间预防 CVD 的潜力知之甚少，并且没有关于它们在人类或动物中的效率的可信证据。在这种情况下，没有体外或体内研究可用。因此，不能明确地说这些酚类化合物的治疗是否对 COVID-19 患者的 CVD 有益。
