Kurepina N E, Khmel' I A
Mol Gen Mikrobiol Virusol. 1986 Apr(4):3-9.
A number of gram-negative bacteria are capable of synthesizing the low molecular mass antibiotics microcins, the substances with molecular masses up to 10 000 D possessing a broad range of antibiotic activity. The synthesis is not lethal for the producing cells and is not induced by DNA-damaging agents. The investigated microcins are either of oligopeptide nature or are analogues of methionine. Five types of microcins have been described. The A- and C-types of microcins inhibit protein synthesis, microcins B suppress DNA replication, microcins D and F affect cellular energy potential. Microcin synthesis and immunity to microcins are shown to be plasmid mediated. The role of microcins in ecology of enterobacteria and the ranking among bacterial antibiotics are discussed.
许多革兰氏阴性菌能够合成低分子量抗生素微菌素，这些物质分子量高达10000道尔顿，具有广泛的抗生素活性。这种合成对产生菌细胞无致死性，且不受DNA损伤剂诱导。所研究的微菌素要么具有寡肽性质，要么是甲硫氨酸类似物。已描述了五种类型的微菌素。A 型和 C 型微菌素抑制蛋白质合成，B 型微菌素抑制 DNA 复制，D 型和 F 型微菌素影响细胞能量潜力。微菌素的合成及对微菌素的免疫性显示由质粒介导。文中讨论了微菌素在肠杆菌生态学中的作用以及在细菌抗生素中的地位。
