Khmel' I A, Manokhina I M, Basiuk E I, Metlitskaia A Z, Lipasova V A, Romanova Iu M, Bondarenko V M
Genetika. 1993 May;29(5):768-76.
As a result of screening among 11956 enterobacteria strains isolated from feces of normal children, grown-ups and lambs, seven active microcin-producing strains were obtained. The microcins were shown to be peptides or their derivatives with a low molecular weight (less than 10,000) and a broad spectrum of activity, mainly against gram-negative bacteria. According to cross immunity criteria the microcins studied belonged to two different types. Those of type I could be further classified into two subtypes on the account of difference in the spectrum of antibacterial activity. In 5 cases out of 7 the microcin-producing ability and immunity to microcins have been attributed to plasmids that the strains harboured. The effect of microcins on sensitive cells depended on ompR and ompF gene products.
对从正常儿童、成人及羔羊粪便中分离出的11956株肠杆菌进行筛选，获得了7株产微菌素的活性菌株。结果表明，微菌素是一类低分子量（小于10,000）的肽或其衍生物，具有广谱活性，主要针对革兰氏阴性菌。根据交叉免疫标准，所研究的微菌素属于两种不同类型。I型微菌素可根据抗菌活性谱的差异进一步分为两个亚型。7株中有5株的产微菌素能力和对微菌素的免疫性归因于菌株所携带的质粒。微菌素对敏感细胞的作用取决于ompR和ompF基因产物。
