Aprelikova O N
Mol Gen Mikrobiol Virusol. 1986 May(5):3-10.
The data confirming the formation of dUMP residues in DNA to be a continuous process taking place in the living cells are reviewed. All living organisms produce specific enzymes repairing the lesion of this type. The possible ways for uracil incorporation into DNA are described. The main of them are as follows: cytosine deamination in DNA molecules and utilization of dUTP by DNA polymerases during replication. The spontaneous mutability, the decrease in chain length of the newly synthesized DNA and the increase in recombination frequencies are discussed as possible consequences of this phenomenon.
本文综述了证实DNA中dUMP残基的形成是一个在活细胞中持续发生的过程的数据。所有生物都会产生修复这类损伤的特定酶。文中描述了尿嘧啶掺入DNA的可能途径。其中主要途径如下：DNA分子中的胞嘧啶脱氨基作用以及复制过程中DNA聚合酶对dUTP的利用。本文还讨论了这种现象可能导致的自发突变、新合成DNA链长度的缩短以及重组频率的增加等后果。
