Glatt H R, Faigle J W, Oesch F
Mutat Res. 1987 Jan;190(1):7-11. doi: 10.1016/0165-7992(87)90074-1.
The tricyclic psychotropic drug opipramol (Insidon) reacts in vitro with sodium nitrite in acidic solution to form products including mutagens for Salmonella typhimurium TA98 and TA100. Two aspects are particularly noteworthy. The strong mutagenicity of the crude reaction mixture is almost exclusively due to a compound which is present only in trace quantities (less than 0.1%). This mutagen was identified as a nitroarene, 4-[3-(2-nitro-9-(10H)-acridinon-10-yl)propyl]-1-piperazine-ethanol . Hence, while the formation of carcinogenic N-nitroso compounds from the interaction of nitrogen-containing compounds with nitrite is well known, the present study demonstrates the formation of a highly mutagenic C-nitro compound in the presence of nitrite.
三环类精神药物奥匹哌醇（因西多）在酸性溶液中与亚硝酸钠在体外发生反应，生成的产物包括对鼠伤寒沙门氏菌TA98和TA100具有致突变性的物质。有两个方面特别值得注意。粗反应混合物的强致突变性几乎完全归因于一种仅以痕量存在（小于0.1%）的化合物。这种诱变剂被鉴定为一种硝基芳烃，即4-[3-(2-硝基-9-(10H)-吖啶酮-10-基)丙基]-1-哌嗪乙醇。因此，虽然含氮化合物与亚硝酸盐相互作用形成致癌的N-亚硝基化合物是众所周知的，但本研究表明在亚硝酸盐存在的情况下会形成一种高度诱变的C-硝基化合物。
