山梨酸-亚硝酸盐反应产生诱变剂：反应条件对生物活性的影响

Formation of mutagens by sorbic acid-nitrite reaction: effects of reaction conditions on biological activities.

作者信息

Namiki M, Udaka S, Osawa T, Tsuji K, Kada T

出版信息

Mutat Res. 1980 Nov;73(1):21-8. doi: 10.1016/0027-5107(80)90132-3.

PMID:7019677

Abstract

Conditions of the reaction between sorbic acid and sodium nitrite generating mutagenic principles were examined. In the rec-assay and the Ames reversion assay, the maximal mutagenic activity was obtained in a pH range of 3.5-4.2. Mutagenic and growth-inhibitor activities of five C-nitro and C-nitroso compounds were studied. The product Y, 2-methyl-1,4-dinitropyrrole, was the strongest mutagen among them.

摘要

研究了山梨酸与亚硝酸钠反应生成诱变剂的反应条件。在重组试验和埃姆斯回复突变试验中，在pH值3.5 - 4.2范围内获得了最大诱变活性。研究了五种C-硝基和C-亚硝基化合物的诱变活性和生长抑制活性。产物Y，即2-甲基-1,4-二硝基吡咯，是其中最强的诱变剂。