National Institute of Biological Sciences, Beijing 102206, China.
Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.
Cells. 2022 Mar 24;11(7):1086. doi: 10.3390/cells11071086.
Autophagy is a conserved process that delivers cytoplasmic components to the vacuole/lysosome. It plays important roles in maintaining cellular homeostasis and conferring stress resistance. In the fission yeast , autophagy is important for cell survival under nutrient depletion and ER stress conditions. Experimental analyses of fission yeast autophagy machinery in the last 10 years have unveiled both similarities and differences in autophagosome biogenesis mechanisms between fission yeast and other model eukaryotes for autophagy research, in particular, the budding yeast . More recently, selective autophagy pathways that deliver hydrolytic enzymes, the ER, and mitochondria to the vacuole have been discovered in fission yeast, yielding novel insights into how cargo selectivity can be achieved in autophagy. Here, we review the progress made in understanding the autophagy machinery in fission yeast.
自噬是一种将细胞质成分输送到液泡/溶酶体的保守过程。它在维持细胞内稳态和赋予应激抗性方面发挥着重要作用。在裂殖酵母中，自噬对于营养物质耗尽和内质网应激条件下的细胞存活至关重要。在过去的 10 年中，对裂殖酵母自噬机制的实验分析揭示了自噬体生物发生机制在裂殖酵母和其他自噬研究的模式真核生物之间的相似性和差异，特别是芽殖酵母。最近，在裂殖酵母中发现了将水解酶、内质网和线粒体递送到液泡的选择性自噬途径，为自噬中如何实现货物选择性提供了新的见解。在这里，我们回顾了在理解裂殖酵母自噬机制方面所取得的进展。
