Palmieri Annalisa, Lauritano Dorina, Pellati Agnese, Scapoli Luca, Arcuri Claudio, Baggi Luigi, Gatto Roberto, Carinci Francesco
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40126 Bologna, Italy.
Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
J Clin Med. 2022 Mar 31;11(7):1935. doi: 10.3390/jcm11071935.
Oral cavity and oropharynx cancer associated with human papil loma virus infection, particularly in young people who are continuously exposed to this virus, is a serious public health problem worldwide, especially for high-risk strains that are most associated with premalignant lesions and tumors. These neoplasms remain asymptomatic for a long time and, when they occur, they are already at an advanced stage. If diagnosed and treated early, oral cancer induced by human papilloma virus allows for high survival, as it often has a more favorable prognosis than oral cancers not directly related to viral infection. In this study, the presence of different high-risk and low-risk HPV strains was investigated to assess the epidemiological status in a population of healthy individuals. Two types of samples, one from the tonsils and one from the base of the tongue, were collected from 2015 healthy individuals of different sex and age. A total of 1885 DNA samples belonging to 1285 patients were tested for the presence of 11 high-risk HPV types plus 4 low-risk HPV types using real-time PCR. Of the patients' DNA samples screened for 15 HPV types, only four samples were positive, all of which were taken from male smokers. These results indicate that newly acquired oral oncogenic HPV infections in the healthy population are rare and, in many cases, controversial. Therefore, more studies are needed to ensure fewer variations in outcomes and a greater clarification of HPV infection and its prevalence in the oropharynx of the healthy population, and to guide efforts to prevent the development of this infection which, if undiagnosed, can lead to the onset of malignant tumors in the oral cavity.
口腔和口咽癌与人乳头瘤病毒感染相关，尤其是在持续接触该病毒的年轻人中，这是一个全球性的严重公共卫生问题，特别是对于与癌前病变和肿瘤关联最大的高危毒株。这些肿瘤在很长一段时间内没有症状，一旦出现往往已处于晚期。如果能早期诊断和治疗，人乳头瘤病毒诱发的口腔癌生存率较高，因为其预后通常比与病毒感染无直接关系的口腔癌更有利。在本研究中，调查了不同高危和低危人乳头瘤病毒毒株的存在情况，以评估健康个体人群中的流行病学状况。从2015名不同性别和年龄的健康个体中采集了两种样本，一种来自扁桃体，一种来自舌根。使用实时聚合酶链反应对属于1285名患者的总共1885份DNA样本进行了11种高危人乳头瘤病毒类型加4种低危人乳头瘤病毒类型的检测。在筛查15种人乳头瘤病毒类型的患者DNA样本中，只有4份样本呈阳性，所有这些样本均取自男性吸烟者。这些结果表明，健康人群中新获得的口腔致癌性人乳头瘤病毒感染很少见，而且在很多情况下存在争议。因此，需要更多的研究来确保结果的差异更小，并更清楚地了解人乳头瘤病毒感染及其在健康人群口咽中的流行情况，以指导预防这种感染发展的工作，因为如果不进行诊断，这种感染可能导致口腔恶性肿瘤的发生。
