Vintzileos A M, Campbell W A, Weinbaum P J, Nochimson D J
Obstet Gynecol. 1987 Jan;69(1):5-11.
In 20 consecutive cases of fetal ventriculomegaly, diagnosed by antenatal ultrasound examination, hydrocephalus was isolated in six patients (30%) and was associated with other anomalies in 14 (70%). There were no false positive diagnoses of fetal ventriculomegaly in this series. Fetal structural and/or chromosome abnormalities were diagnosed antenatally in 11 of the 14 patients (78.5%) with postnatally documented anomalies. In ten patients (50%), isolated fetal ventriculomegaly or ventriculomegaly associated with spina bifida was diagnosed antenatally, and the perinatal management consisted of frequent ultrasound examinations, weekly fetal biophysical profiles, and delivery by cesarean section after documenting fetal lung maturity. Ventriculo-amniotic shunt placement was not part of the management. The outcomes were induced abortion, four patients (20%); intrapartum death, two patients (10%); postnatal death, five patients (25%); and currently alive, nine patients (45%).
在通过产前超声检查诊断出的20例连续胎儿脑室扩大病例中，6例（30%）为孤立性脑积水，14例（70%）合并其他异常。本系列中胎儿脑室扩大无假阳性诊断。14例出生后记录有异常的患者中，11例（78.5%）产前诊断出胎儿结构和/或染色体异常。10例（50%）患者产前诊断为孤立性胎儿脑室扩大或合并脊柱裂的脑室扩大，围产期管理包括频繁超声检查、每周进行胎儿生物物理评分，以及在记录胎儿肺成熟后行剖宫产分娩。脑室 - 羊膜分流置管不属于管理措施。结局为人工流产4例（20%）；产时死亡2例（10%）；产后死亡5例（25%）；目前存活9例（45%）。
