Chervenak F A, Duncan C, Ment L R, Hobbins J C, McClure M, Scott D, Berkowitz R L
Lancet. 1984 Jul 28;2(8396):179-81. doi: 10.1016/s0140-6736(84)90477-x.
Ventriculomegaly was diagnosed in 50 fetuses in the perinatal ultrasound unit of Yale-New Haven Medical Center. The outcomes were elective abortion, 13 (26%); antepartum death, 0 (0%); intrapartum death, 7 (14%); neonatal death within 24 h, 11 (22%); neonatal death after 24 h and within 28 days, 3 (6%); death after 28 days, 2 (4%); survival, 14 (28%). 70% of the deaths were associated with severe congenital anomalies or intrapartum cephalocentesis. Of the 14 survivors, 6 (43%) had Bayley mental or Stanford-Binet scores of over 80, 2 (14%) had scores from 65 to 80, and 6 (43%) had scores of less than 65. The differences in outcome between this antenatal population and previously described neonatal populations with ventriculomegaly may result from the high rate (84%) of abnormalities in association with ventriculomegaly in this study and selection biases in neonatal studies.
在耶鲁-纽黑文医疗中心围产期超声科诊断出50例胎儿患有脑室扩大。其结局为：选择性流产13例（26%）；产前死亡0例（0%）；产时死亡7例（14%）；24小时内新生儿死亡11例（22%）；24小时后至28天内新生儿死亡3例（6%）；28天后死亡2例（4%）；存活14例（28%）。70%的死亡与严重先天性异常或产时头颅穿刺术有关。在14名存活者中，6名（43%）贝利智力发育指数或斯坦福-比奈智力量表得分超过80分，2名（14%）得分在65至80分之间，6名（43%）得分低于65分。该产前人群与先前描述的患有脑室扩大的新生儿人群在结局上的差异，可能是由于本研究中与脑室扩大相关的异常发生率较高（84%）以及新生儿研究中的选择偏倚所致。
