Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague, Czech Republic.
Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoy pr., 31, 199004 Saint-Petersburg, Russia.
Sensors (Basel). 2022 Apr 5;22(7):2784. doi: 10.3390/s22072784.
The main task of the research is to acquire fundamental knowledge about the effect of polymer structure on the physicochemical properties of films. A novel meta-material that can be used in manufacturing sensor layers was developed as a model. At the first stage, poly(sodium 4-styrenesulfonate) () cross-linked microspheres are synthesized (which are based on strong polyelectrolytes containing sulfo groups in each monomer unit), and at the second stage, microspheres are formed. The poly(3,4-ethylenedioxythiophene) () shell was obtained by the acid-assisted self-polymerization of the monomer; this process is biologically safe and thus suitable for biomedical applications. The suitability of electrochemical impedance spectroscopy for detection was tested; it was revealed that the attached bacterial wall was destroyed upon application of constant oxidation potential (higher than 0.5 V), which makes the microsphere particles promising materials for the development of antifouling coatings. Furthermore, under open-circuit conditions, the walls of bacteria were not destroyed, which opens up the possibility of employing such meta-materials as sensor films. Scanning electron microscopy, X-ray photoelectron spectroscopy, water contact angle, and wide-angle X-ray diffraction methods were applied in order to characterize the films.
研究的主要任务是获得关于聚合物结构对薄膜物理化学性质影响的基本知识。以一种新型的可用于制造传感器层的介孔材料为模型。在第一阶段，合成了交联的聚（4-苯乙烯磺酸钠）（）微球（其基于每个单体单元中都含有磺酸基团的强聚电解质），然后在第二阶段形成了微球。聚（3,4-亚乙基二氧噻吩）（）壳是通过单体的酸辅助自聚合获得的；该过程在生物上是安全的，因此适用于生物医学应用。测试了电化学阻抗谱对的检测适用性；结果表明，当施加恒定氧化电位（高于 0.5 V）时，附着的细菌细胞壁被破坏，这使得微球颗粒成为开发抗污涂层的有前途的材料。此外，在开路条件下，细菌的细胞壁没有被破坏，这为将这种介孔材料用作传感器薄膜开辟了可能性。为了对薄膜进行表征，应用了扫描电子显微镜、X 射线光电子能谱、水接触角和广角 X 射线衍射方法。
