薄荷油对 APP/PS1 转基因小鼠学习记忆能力的影响。

Effects of Peppermint Essential Oil on Learning and Memory Ability in APP/PS1 Transgenic Mice.

机构信息

School of Design, Shanghai Jiao Tong University, Shanghai 201100, China.

Mental Health Centre, Medical College, Shanghai Jiaotong University, Shanghai 200240, China.

出版信息

Molecules. 2022 Mar 22;27(7):2051. doi: 10.3390/molecules27072051.

OBJECTIVE

To explore the effect and mechanism of peppermint essential oil on learning and memory ability of APP/PS1 transgenic mice.

METHODS

Morris water maze test and shuttle box test were used to explore the changes in learning and memory ability of APP/PS1 transgenic mice after sniffing essential oil. The cellular status of neurons in the hippocampal CA1 region of the right hemisphere, Aβ deposition, oxidative stress level, and serum metabonomics were detected to explore its mechanism.

RESULTS

Sniffing peppermint essential oil can improve the learning and memory ability of APP/PS1 transgenic mice. Compared with the model group, the state of neurons in the hippocampal CA1 region of the peppermint essential oil group returned to normal, and the deposition of Aβ decreased. The MDA of brain tissue decreased significantly, and the activity of SOD and GSH-PX increased significantly to the normal level. According to the results of metabonomics, it is speculated that peppermint essential oil may improve cognitive function in AD by regulating arginine and proline metabolism, inositol phosphate metabolism, and cysteine and methionine metabolism.

目的

探索薄荷油对 APP/PS1 转基因小鼠学习记忆能力的影响及其作用机制。

方法

采用 Morris 水迷宫实验和穿梭箱实验，观察嗅吸薄荷油后 APP/PS1 转基因小鼠学习记忆能力的变化，检测右侧海马 CA1 区神经元细胞状态、Aβ 沉积、氧化应激水平及血清代谢组学变化，探讨其作用机制。

结果

嗅吸薄荷油可改善 APP/PS1 转基因小鼠的学习记忆能力，与模型组比较，薄荷油组小鼠海马 CA1 区神经元状态恢复正常，Aβ 沉积减少，脑组织 MDA 显著降低，SOD、GSH-PX 活性明显升高至正常水平。代谢组学结果提示，薄荷油可能通过调控精氨酸和脯氨酸代谢、肌醇磷酸代谢、半胱氨酸和蛋氨酸代谢等途径改善 AD 认知功能。