阿尔茨海默病。

Alzheimer's disease.

机构信息

Dementia Research Centre, UCL Institute of Neurology, London, UK.

Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.

出版信息

Eur J Neurol. 2018 Jan;25(1):59-70. doi: 10.1111/ene.13439. Epub 2017 Oct 19.

DOI:10.1111/ene.13439

PMID:28872215

Abstract

Alzheimer's disease, the commonest cause of dementia, is a growing global health concern with huge implications for individuals and society. In this review, current understanding of the epidemiology, genetics, pathology and pathogenesis of Alzheimer's disease is outlined, before its clinical presentation and current treatment strategies are discussed. Finally, the review discusses how our enhanced understanding of Alzheimer pathogenesis, including the recognition of a protracted preclinical phase, is informing new therapeutic strategies with the aim of moving from treatment to prevention.

摘要

阿尔茨海默病是最常见的痴呆症病因，是一个日益严重的全球性健康问题，对个人和社会都有重大影响。本文首先概述了目前对阿尔茨海默病的流行病学、遗传学、病理学和发病机制的认识，然后讨论其临床表现和当前的治疗策略。最后，本文讨论了我们对阿尔茨海默病发病机制的认识的提高，包括认识到一个漫长的临床前阶段，如何为新的治疗策略提供信息，旨在从治疗转向预防。