从中分离出一种黑素细胞刺激素，对其进行结构修饰，并研究其对白癜风的结构活性关系。

Isolation of a Melanoblast Stimulator from , Its Structural Modification, and Structure-Activity Relationships for Vitiligo.

机构信息

Department of Chemistry and Chemical Engineering, Inha University, Incheon 22212, Korea.

Department of Biological Engineering, Inha University, Incheon 22212, Korea.

出版信息

Molecules. 2022 Mar 25;27(7):2135. doi: 10.3390/molecules27072135.

DOI:10.3390/molecules27072135

PMID:35408531

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9000856/

Abstract

A novel melanoblast stimulator () was isolated from . Its analogs were also synthesized to support a new furan-based melanoblast stimulator scaffold for treating vitiligo. Isolated 5-(hydroxymethyl)furfural (HMF, ) is a well-known compound in the food industry. Surprisingly, the melanogenic activity of HMF () was discovered here for the first time. Both HMF and its synthetic analog () promote the differentiation and migration of melanoblasts in vitro. Typically, stimulator () upregulated MMP2 expression, which promoted the migration of melanoblasts in vitro.

摘要

一种新型的黑素细胞刺激剂（）从中分离出来。还合成了它的类似物，以支持一种基于呋喃的新型黑素细胞刺激剂支架，用于治疗白癜风。分离出的 5-（羟甲基）糠醛（HMF，）是食品工业中一种众所周知的化合物。令人惊讶的是，在这里首次发现了 HMF（）的黑色素生成活性。HMF 和其合成类似物（）都能促进体外黑素细胞的分化和迁移。通常，刺激剂（）上调 MMP2 的表达，从而促进黑素细胞在体外的迁移。