Niu Chao, Aisa Haji A
Key Laboratory of Plant Resources and Chemistry of Arid Zone, Chinese Academy of Sciences, Urumqi 830011, China.
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
Molecules. 2017 Aug 4;22(8):1303. doi: 10.3390/molecules22081303.
Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. The abnormal loss of melanin causes dermatological problems such as vitiligo. Hence the regulation of melanogenesis and tyrosinase activity is very important for treating hypopigmentary disorders. Many melanogenesis stimulators have been discovered during the past decade. This article reviews recent advances in research on extracts and active ingredients of plants, synthesized compounds with stimulating effect on melanin synthesis and tyrosinase activity, as well as their influence on the expression of related proteins and possible signaling pathways for the design and development of novel anti-vitiligo agents.
黑色素是人类头发、眼睛和皮肤色素沉着的主要化合物，由黑素细胞通过一个称为黑素生成的复杂过程产生，该过程由酪氨酸酶和其他酪氨酸酶相关蛋白催化。黑色素的异常流失会导致白癜风等皮肤病问题。因此，黑素生成和酪氨酸酶活性的调节对于治疗色素减退性疾病非常重要。在过去十年中发现了许多黑素生成刺激剂。本文综述了植物提取物和活性成分、对黑色素合成和酪氨酸酶活性有刺激作用的合成化合物的研究进展，以及它们对相关蛋白表达的影响和可能的信号通路，为新型抗白癜风药物的设计和开发提供参考。
