Stimmel G L, Escobar J I
Pharmacotherapy. 1986 Sep-Oct;6(5):262-7. doi: 10.1002/j.1875-9114.1986.tb03486.x.
Antidepressant drugs have gained widespread clinical usage alone or as adjuncts in the treatment of chronic pain disorders. Of 17 controlled studies of antidepressants in chronic pain, 13 demonstrated significant pain relief with antidepressants compared to placebo. These studies were too different from one another to allow any general conclusions concerning efficacy, however. Five studies of either migraine or chronic tension headache all demonstrated superior efficacy of antidepressants versus placebo, while those of back and arthritic pain yielded mixed results. Of 3 studies of pain of several etiologies, 2 failed to demonstrate efficacy of antidepressants over placebo. These studies do not provide answers to many clinical questions on the use of antidepressants for chronic pain, such as drug of choice or appropriate dosage. Rather, they suggest that these agents may be beneficial in some patients with chronic pain.
抗抑郁药物已在临床上广泛单独使用或作为辅助药物用于治疗慢性疼痛疾病。在17项关于抗抑郁药物治疗慢性疼痛的对照研究中，13项研究表明与安慰剂相比，抗抑郁药物能显著缓解疼痛。然而，这些研究彼此差异太大，无法得出关于疗效的任何一般性结论。五项关于偏头痛或慢性紧张性头痛的研究均表明，与安慰剂相比，抗抑郁药物具有更高的疗效，而关于背痛和关节炎疼痛的研究结果则喜忧参半。在三项针对多种病因引起的疼痛的研究中，有两项未能证明抗抑郁药物比安慰剂更有效。这些研究并未回答许多关于使用抗抑郁药物治疗慢性疼痛的临床问题，例如首选药物或合适剂量。相反，它们表明这些药物可能对一些慢性疼痛患者有益。
