France R D, Houpt J L, Ellinwood E H
Gen Hosp Psychiatry. 1984 Jan;6(1):55-63. doi: 10.1016/0163-8343(84)90060-4.
Depression and chronic pain syndromes are often associated. Over the last twenty years there has been a number of controlled and uncontrolled studies evaluating the efficacy of antidepressants in various pain problems. The administration of antidepressant medications in the management of chronic pain has become a commonly prescribed therapeutic modality in the treatment of this complex syndrome. This paper reviews the clinical studies in which antidepressants have been used to control chronic pain, summarizes the results of the clinical studies, and comments on the mechanism of action of antidepressants in chronic pain.
抑郁症与慢性疼痛综合征常常相伴。在过去二十年里，有许多对照和非对照研究评估了抗抑郁药在各种疼痛问题中的疗效。在慢性疼痛管理中使用抗抑郁药物已成为治疗这一复杂综合征时常用的一种治疗方式。本文回顾了使用抗抑郁药控制慢性疼痛的临床研究，总结了临床研究结果，并对抗抑郁药在慢性疼痛中的作用机制进行了评论。
