School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325015, China.
Int J Mol Sci. 2022 Mar 25;23(7):3589. doi: 10.3390/ijms23073589.
() is a common commensal bacterium that is closely associated with the pathogenesis of acne. Fibroblast growth factor 21 (FGF21), as a favorable regulator of glucose and lipid metabolism and insulin sensitivity, was recently shown to exert anti-inflammatory effects. The role and mechanism of FGF21 in the inflammatory reactions induced by , however, have not been determined. The present study shows that FGF21 in the dermis inhibits epidermal -induced inflammation in a paracrine manner while it functions on the epidermal layer through a receptor complex consisting of FGF receptor 1 (FGFR1) and β-Klotho (KLB). The effects of FGF21 in heat-killed -induced HaCaT cells and living -injected mouse ears were examined. In the presence of , FGF21 largely counteracted the activation of Toll-like receptor 2 (TLR2), the downstream nuclear factor-κB (NF-κB), and mitogen-activated protein kinase (MAPK) signaling pathways induced by . FGF21 also significantly reduced the expression of proinflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α. Taken together, these findings indicate that FGF21 suppresses -induced inflammation and might be used clinically in the management and treatment of acne.
痤疮丙酸杆菌是一种常见的共生菌，与痤疮的发病机制密切相关。成纤维细胞生长因子 21（FGF21）作为葡萄糖和脂质代谢以及胰岛素敏感性的有利调节剂，最近被证明具有抗炎作用。然而，FGF21 在 诱导的炎症反应中的作用和机制尚未确定。本研究表明，真皮中的 FGF21 通过由成纤维细胞生长因子受体 1（FGFR1）和 β-Klotho（KLB）组成的受体复合物以旁分泌方式抑制表皮诱导的炎症，而在表皮层通过该受体复合物发挥作用。研究了 FGF21 在热灭活 诱导的 HaCaT 细胞和活体注射的小鼠耳朵中的作用。在 的存在下，FGF21 很大程度上抵消了由 诱导的 Toll 样受体 2（TLR2）、下游核因子-κB（NF-κB）和丝裂原活化蛋白激酶（MAPK）信号通路的激活。FGF21 还显著降低了促炎细胞因子，包括白细胞介素（IL）-1β、IL-6、IL-8 和肿瘤坏死因子（TNF）-α的表达。综上所述，这些发现表明 FGF21 抑制 诱导的炎症，并且可能在痤疮的管理和治疗中临床应用。
